Abstract
Lung cancer kills more Americans yearly than any other neoplastic process. Mortality rates have changed little over the past several decades, despite improvements in surgical techniques, radiation therapy and chemotherapy. The identification of mutations in oncogenes and tumor suppressor genes in human lung tumor specimens, including K-ras, p53, p16INK4a and Rb, offers molecular explanations for tumor development and resistance to therapy. Mouse models of human lung cancer may advance our understanding of this disease. The examination of mice which develop lung cancer either spontaneously or due to carcinogen exposure, and the creation of mouse strains harboring the specific genetic mutations found in human lung cancer are among strategies being pursued.
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References
Aguayo SM, Miller YE, Waldron Jr JA, Bogin RM, Sunday ME, Staton Jr GW, Beam WR and King Jr TE. . 1992 N. Engl. J. Med. 327: 1285–1288.
Andervont HB and Shimkin MB. . 1940 J. Natl. Cancer Inst. 1: 225–239.
Auerbach O, Stout AP, Hammond EC and Garfinkel L. . 1961 N. Eng. J. Med. 256: 253–267.
Balsara BR, Sonoda G, du Manoir S, Siegfried JM, Gabrielson E and Testa JR. . 1997 Cancer Res. 57: 2116–2120.
Brauch H, Johnson B, Hovis J, Yano T, Gazdar A, Pettengill OS, Graziano S, Sorenson GD, Poiesz BJ, Minna J, Linehan M and Zbar B. . 1987 N. Engl. J. Med. 317: 1109–1113.
Chen B, Johanson L, Wiest JS, Anderson MW and You M. . 1994a Proc. Natl. Acad. Sci. USA 91: 1589–1593.
Chen B, You L, Wang Y, Stoner GD and You M. . 1994b Carcinogenesis 15: 2031–2035.
Chin L, Pomerantz J, Polsky D, Jacobson M, Cohen C, Cordon-Cardo C, Horner 2nd JW and DePinho RA. . 1997 Genes Dev. 11: 2822–2834.
Clarke AR, Maandag ER, van Roon M, van der Lugt NM, van der Valk M, Hooper ML, Berns A and te Riele H. . 1992 Nature 359: 328–330.
D'Agati VD and Perzin KH. . 1985 Cancer 55: 2472–2476.
D'Amico D, Carbone D, Mitsudomi T, Nau M, Fedorko J, Russell E, Johnson B, Buchhagen D, Bodner S, Phelps R, Gazdar A and Minna JD. . 1992 Oncogene 7: 339–346.
Devereux TR, Wiseman RW, Kaplan N, Garren S, Foley JF, White CM, Anna C, Watson MA, Patel A and Jarchow S. . 1994 Mamm. Genome 5: 749–755.
Dixon D, Horton J, Haseman JK, Talley F, Greenwell A, Nettesheim P, Hook GE and Maronpot RR. . 1991 Exp. Lung Res. 17: 131–155.
Donehower LA, Harvey M, Slagle BL, McArthur MJ, Montgomery Jr CA, Butel JS and Bradley A. . 1992 Nature 356: 215–221.
Donehower LA, Godley LA, Aldaz CM, Pyle R, Shi YP, Pinkel D, Gray J, Bradley A, Medina D and Varmus HE. . 1995 Genes Dev. 9: 882–895.
Festing MF, Yang A and Malkinson AM. . 1994 Genet. Res. 64: 99–106.
Fijneman RJ, de Vries SS, Jansen RC and Demant P. . 1996 Nat. Genet. 14: 465–467.
Foley JF, Anderson MW, Stoner GD, Gaul BW, Hardisty JF and Maronpot RR. . 1991 Exp. Lung Res. 17: 157–168.
Gariboldi M, Manenti G, Canzian F, Falvella FS, Radice MT, Pierotti MA, Della Porta G, Binelli G and Dragani TA. . 1993 Nat. Genet. 3: 132–136.
Glover TW, Hoge AW, Miller DE, Ascara-Wilke JE, Adam AN, Dagenais SL, Wilke CM, Dierick HA and Beer DG. . 1998 Cancer Res. 58: 3409–3414.
Harvey RG. . 1991 Polycyclic Aromatic Hydrocarbons, Chemistry and Carcinogenesis. Cambridge University Press: Cambridge.
Hecht SS, Morse MA, Amin S, Stoner GD, Jordan KG, Choi CI and Chung FL. . 1989 Carcinogenesis 10: 1901–1904.
Hensel CH, Hsieh CL, Gazdar AF, Johnson BE, Sakaguchi AY, Naylor SL, Lee WH and Lee EY. . 1990 Cancer Res. 50: 3067–3072.
Hensel CH, Xiang RH, Sakaguchi AY and Naylor SL. . 1991 Oncogene 6: 1067–1071.
Herzog CR, Wiseman RW and You M. . 1994 Cancer Res. 54: 4007–4010.
Herzog CR, Soloff EV, McDoniels AL, Tyson FL, Malkinson AM, Haugen-Strano A, Wiseman RW, Anderson MW and You M. . 1996 Oncogene 13: 1885–1891.
Horio Y, Chen A, Rice P, Roth JA, Malkinson AM and Schrump DS. . 1996 Mol. Carcinog. 17: 217–223.
Jacks T, Fazeli A, Schmitt EM, Bronson RT, Goodell MA and Weinberg RA. . 1992 Nature 359: 295–300.
Jacks T, Remington L, Williams BO, Schmitt EM, Halachmi S, Bronson RT and Weinberg RA. . 1994 Curr. Biol. 4: 1–7.
Johnson BE, Ihde DC, Makuch RW, Gazdar AF, Carney DN, Oie H, Russell E, Nau MM and Minna JD. . 1987 J. Clin. Invest. 79: 1629–1634.
Kamb A, Shattuck-Eidens D, Eeles R, Liu Q, Gruis NA, Ding W, Hussey C, Tran T, Miki Y, Weaver-Feldhaus J, McClure M, Aitken JF, Anderson DE, Bergman W, Frants R, Goldgar DE, Green A, MacLennan R, Martin NG, Meyer LJ, Youl P, Zone JJ, Skolnick MH and Cannon-Albright LA. . 1994 Nat. Genet. 8: 23–26.
Kern JA, Schwartz DA, Nordberg JE, Weiner DB, Greene MI, Torney L and Robinson RA. . 1990 Cancer Res. 50: 5184–5187.
Kim SH and Lee CS. . 1996 Anticancer Res. 16: 465–470.
Kohl NE, Mosser SD, deSolms SJ, Giuliani EA, Pompliano DL, Graham SL, Smith RL, Scolnick EM, Oliff A and Gibbs JB. . 1993 Science 260: 1934–1937.
Kondo K, Umemoto A, Akimoto S, Uyama T, Hayashi K, Ohnishi Y and Monden Y. . 1992 Biochem. Biophys. Res. Commun. 183: 1139–1146.
Landis SH, Murray T, Bolden S and Wingo PA. . 1998 CA Cancer J. Clin. 48: 6–29.
Lavigueur A, Maltby V, Mock D, Rossant J, Pawson T and Bernstein A. . 1989 Mol. Cell. Biol. 9: 3982–3991.
Lee EY, Chang CY, Hu N, Wang YC, Lai CC, Herrup K, Lee WH and Bradley A. . 1992 Nature 359: 288–294.
Lin L, Festing MF, Devereux TR, Crist KA, Christiansen SC, Wang Y, Yang A, Svenson K, Paigen B, Malkinson AM and You M. . 1998 Exp. Lung Res. 24: 481–497.
Little CD, Nau MM, Carney DN, Gazdar AF and Minna JD. . 1983 Nature 306: 194–196.
Lopez AD. . 1999 Bull World Health Organ. 77: 82–83.
Lynch CI. . 1926 J. Exp. Med. 43: 339–355.
Mabry M, Nakagawa T, Nelkin BD, McDowell E, Gesell M, Eggleston JC, Casero Jr RA and Baylin SB. . 1988 Proc. Natl. Acad. Sci. USA 85: 6523–6527.
Malkinson AM, Nesbitt MN and Skamene E. . 1985 J. Natl. Cancer Inst. 75: 971–974.
Manenti G, Gariboldi M, Elango R, Fiorino A, De Gregorio L, Falvella FS, Hunter K, Housman D, Pierotti MA and Dragani TA. . 1996 Nat. Genet. 12: 455–457.
Manenti G, Gariboldi M, Fiorino A, Zanesi N, Pierotti MA and Dragani TA. . 1997 Cancer Res. 57: 4164–4166.
Mao L, Hruban RH, Boyle JO, Tockman M and Sidransky D. . 1994 Cancer Res. 54: 1634–1637.
Mao L, Lee JS, Kurie JM, Fan YH, Lippman SM, Lee JJ, Ro JY, Broxson A, Yu R, Morice RC, Kemp BL, Khuri FR, Walsh GL, Hittelman WN and Hong WK. . 1997 J. Natl. Cancer Inst. 89: 857–862.
Maronpot RR, Palmiter RD, Brinster RL and Sandgren EP. . 1991 Exp. Lung Res. 17: 305–320.
Merlo A, Herman JG, Mao L, Lee DJ, Gabrielson E, Burger PC, Baylin SB and Sidransky D. . 1995 Nat. Med. 1: 686–692.
Mertens F, Johansson B, Hoglund M and Mitelman F. . 1997 Cancer Res. 57: 2765–2780.
Mills NE, Fishman CL, Rom WN, Dubin N and Jacobson DR. . 1995 Cancer Res. 55: 1444–1447.
Mitsudomi T, Steinberg SM, Nau MM, Carbone D, D'Amico D, Bodner S, Oie HK, Linnoila RI, Mulshine JL, Minna JD and Gazdar AF. . 1992 Oncogene 7: 171–180.
MMWR. . 1996 Morb. Mortal Wkly. Rep. 45: 971–974.
Nakanishi K. . 1990 Arch. Pathol. Lab. Med. 114: 363–368.
Nesbitt JC, Lee JS, Komaki R and Roth JA. . 1997 Cancer Medicine. In: Holland JF, Bast RC, Morton D, Frei E, Kufe D and Weichselbaum RR (eds).. Williams and Wilkins: Baltimore pp1723–1803.
Noguchi M, Hirohashi S, Hara F, Kojima A, Shimosato Y, Shinkai T and Tsuchiya R. . 1990 Cancer 66: 2053–2058.
Obata M, Nishimori H, Ogawa K and Lee GH. . 1996 Oncogene 13: 1599–1604.
Okamoto A, Demetrick DJ, Spillare EA, Hagiwara K, Hussain SP, Bennett WP, Forrester K, Gerwin B, Serrano M, Beach DH and Harris CC. . 1994 Proc. Natl. Acad. Sci. USA 91: 11045–11049.
Okamoto A, Hussain SP, Hagiwara K, Spillare EA, Rusin MR, Demetrick DJ, Serrano M, Hannon GJ, Shiseki M, Zariwala M, Xiong Y, Beach DH, Yokota J and Harris CC. . 1995 Cancer Res. 55: 1448–1451.
Pataer A, Nishimura M, Kamoto T, Ichioka K, Sato M and Hiai H. . 1997 Cancer Res. 57: 2904–2908.
Pekarsky Y, Druck T, Cotticelli MG, Ohta M, Shou J, Mendrola J, Montgomery JC, Buchberg AM, Siracusa LD, Manenti G, Fong LY, Dragani TA, Croce CM and Huebner K. . 1998 Cancer Res. 58: 3401–3408.
Petersen I, Bujard M, Petersen S, Wolf G, Goeze A, Schwendel A, Langreck H, Gellert K, Reichel M, Just K, du Manoir S, Cremer T, Dietel M and Ried T. . 1997 Cancer Res. 57: 2331–2335.
Pezzella F, Turley H, Kuzu I, Tungekar MF, Dunnill MS, Pierce CB, Harris A, Gatter KC and Mason DY. . 1993 N. Engl. J. Med. 329: 690–694.
Reissmann PT, Koga H, Takahashi R, Figlin RA, Holmes EC, Piantadosi S, Cordon Cardo C and Slamon DJ. . 1993 Oncogene 8: 1913–1919.
Ries LA. . 1994 Semin. Surg. Oncol. 10: 21–30.
Rodenhuis S and Slebos RJ. . 1990 Am. Rev. Respir. Dis. 142: S27–S30.
Roggli VL, Vollmer RT, Greenberg SD, McGavran MH, Spjut HJ and Yesner R. . 1985 Hum. Pathol. 16: 569–579.
Ronai ZA, Gradia S, Peterson LA and Hecht SS. . 1993 Carcinogenesis 14: 2419–2422.
Ryberg D, Lindstedt BA, Zienolddiny S and Haugen A. . 1995 Cancer Res. 55: 3996–3999.
Saitoh A, Kimura M, Takahashi R, Yokoyama M, Nomura T, Izawa M, Sekiya T, Nishimura S and Katsuki M. . 1990 Oncogene 5: 1195–1200.
Sameshima Y, Matsuno Y, Hirohashi S, Shimosato Y, Mizoguchi H, Sugimura T, Terada M and Yokota J. . 1992 Oncogene 7: 451–457.
Sandmoller A, Halter R, Suske G, Paul D and Beato M. . 1995 Cell Growth Differ. 6: 97–103.
Sauer B and Henderson N. . 1988 Proc. Natl. Acad. Sci. USA 85: 5166–5170.
Schauer IE, Siriwardana S, Langan TA and Sclafani RA. . 1994 Proc. Natl. Acad. Sci. USA 91: 7827–7831.
Serrano M, Lee H, Chin L, Cordon-Cardo C, Beach D and DePinho RA. . 1996 Cell 85: 27–37.
Shapiro GI, Edwards CD, Kobzik L, Godleski J, Richards W, Sugarbaker DJ and Rollins BJ. . 1995 Cancer Res. 55: 505–509.
Shimkin MB. . 1940 J. Natl. Cancer Inst. 1: 241–254.
Shimkin MB. . 1955 Adv Cancer Res. 3: 223–267.
Shimkin MB and Stoner GD. . 1975 Adv Cancer Res. 21: 1–58.
Shiseki M, Kohno T, Adachi J, Okazaki T, Otsuka T, Mizoguchi H, Noguchi M, Hirohashi S and Yokota J. . 1996 Genes Chromosomes Cancer 17: 71–77.
Shopland DR, Eyre HJ and Pechacek TF. . 1991 J. Natl. Cancer Inst. 83: 1142–1148.
Slebos RJ, Kibbelaar RE, Dalesio O, Kooistra A, Stam J, Meijer CJ, Wagenaar SS, Vanderschueren RG, van Zandwijk N, Mooi WJ, Bos JL and Rodenhuis S. . 1990 N. Engl. J. Med. 323: 561–565.
Sozzi G, Miozzo M, Pastorino U, Pilotti S, Donghi R, Giarola M, De Gregorio L, Manenti G, Radice P, Minoletti F, Della Porta G and Peirotti MA. . 1995 Cancer Res. 55: 135–140.
Sozzi G, Veronese ML, Negrini M, Baffa R, Cotticelli MG, Inoue H, Tornielli S, Pilotti S, De Gregorio L, Pastorino U, Pierotti MA, Ohta M, Huebner K and Croce CM. . 1996 Cell 85: 17–26.
Stewart HL, Dunn TB, Snell KC and Deringer MK. . 1979 Pathology of Tumors in Laboratory Animals. In: Turosov VS (ed).. IARC press: Lyon pp251–288.
Stoner GD. . 1991 Exp. Lung Res. 17: 405–423.
Stoner GD, Adam-Rodwell G and Morse MA. . 1993 J. Cell. Biochem. Suppl. 17F: 95–103.
Suda Y, Aizawa S, Hirai S, Inoue T, Furuta Y, Suzuki M, Hirohashi S and Ikawa Y. . 1987 EMBO J. 6: 4055–4065.
Suzuki K, Ogura T, Yokose T, Sekine I, Nagai K, Kodama T, Mukai K, Nishiwaki Y and Esumi H. . 1998 Br. J. Cancer 77: 1003–1008.
Takahashi T, Obata Y, Sekido Y, Hida T, Ueda R, Watanabe H, Ariyoshi Y and Sugiura T. . 1989 Cancer Res. 49: 2683–2688.
Takahashi T, Suzuki H, Hida T, Sekido Y, Ariyoshi Y and Ueda R. . 1991 Oncogene 6: 1775–1778.
Thaete LG and Malkinson AM. . 1991 Exp. Lung Res. 17: 219–228.
Virmani AK, Fong KM, Kodagoda D, McIntire D, Hung J, Tonk V, Minna JD and Gazdar AF. . 1998 Genes Chromosomes Cancer 21: 308–319.
Wattenberg LW and Leong JL. . 1970 Cancer Res. 30: 1922–1925.
Weiner DB, Nordberg J, Robinson R, Nowell PC, Gazdar A, Greene MI, Williams WV, Cohen JA and Kern JA. . 1990 Cancer Res. 50: 421–425.
Weiss KM. . 1998 Genome Res. 8: 691–697.
WHO. . 1982 Am. J. Clin. Pathol. 77: 123–136.
Wikenheiser KA, Clark JC, Linnoila RI, Stahlman MT and Whitsett JA. . 1992 Cancer Res. 52: 5342–5352.
Williams BO, Remington L, Albert DM, Mukai S, Bronson RT and Jacks T. . 1994 Nature Genetics 7: 480–484.
Wiseman RW, Cochran C, Dietrich W, Lander ES and Soderkvist P. . 1994 Proc. Natl. Acad. Sci. USA 91: 3759–3763.
Wistuba II, Lam S, Behrens C, Virmani AK, Fong KM, LeRiche J, Samet JM, Srivastava S, Minna JD and Gazdar AF. . 1997 J. Natl. Cancer Inst. 89: 1366–1373.
Witschi H, Espiritu I, Maronpot RR, Pinkerton KE and Jones AD. . 1997 Carcinogenesis 18: 2035–2042.
Witschi H. . 1998 Exp. Lung Res. 24: 385–394.
Xiao S, Li D, Corson JM, Vijg J and Fletcher JA. . 1995 Cancer Res. 55: 2968–2971.
Xu HJ, Hu SX, Cagle PT, Moore GE and Benedict WF. . 1991 Cancer Res. 51: 2735–2739.
Yokota J, Akiyama T, Fung YK, Benedict WF, Namba Y, Hanaoka M, Wada M, Terasaki T, Shimosato Y, Sugimura T and Terada M. . 1988 Oncogene 3: 471–475.
You M, Candrian U, Maronpot RR, Stoner GD and Anderson MW. . 1989 Proc. Natl. Acad. Sci. USA 86: 3070–3074.
You M, Wang Y, Stoner G, You L, Maronpot R, Reynolds SH and Anderson M. . 1992 Proc. Natl. Acad. Sci. USA 89: 5804–5808.
Acknowledgements
We thank Drs Sunil Hingorani and Julien Sage for reviewing this manuscript. DA Tuveson is supported by an NCI oncology fellowship training grant (T32CA71345). T Jacks is an Associate Investigator of the Howard Hughes Medical Institute.
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Tuveson, D., Jacks, T. Modeling human lung cancer in mice: similarities and shortcomings. Oncogene 18, 5318–5324 (1999). https://doi.org/10.1038/sj.onc.1203107
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