Chromatin-remodeling enzymes perform the formidable task of reorganizing the structure of a stable macromolecular assembly, the nucleosome. Recently published work demonstrates that the SNF2H chromatin remodeler distorts the histone octamer structure upon binding to the nucleosome, then taps into this induced plasticity to productively achieve nucleosome sliding.
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Acknowledgements
We acknowledge support from the Deutsche Forschungsgemeinschaft (SFB 646 and 1064 to A.G.L.; SFB 1064 to H.R.S.) and from the European Commission (Marie Skłodowska Curie Individual Fellowship 'SilentFACT' and H2020-MSCA-IF-2014 contract 657244 to M.M.).
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A.G.L. is on the Scientific Advisory Board of VolitionRx, Inc.
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Singh, H., Murawska, M. & Ladurner, A. Remodelers tap into nucleosome plasticity. Nat Struct Mol Biol 24, 341–343 (2017). https://doi.org/10.1038/nsmb.3394
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DOI: https://doi.org/10.1038/nsmb.3394
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