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In this Review, Wiedenheft and colleagues retrace events that led from early endeavours to understand the role of Cas9 in CRISPR-mediated adaptive immunity to current efforts aimed at developing this enzyme for programmable genetic editing.
Shah and Kuriyan highlight how the analysis of sequence variation synergizes with protein structure information, to provide new insights into specificity and allosteric regulation of signaling proteins.
Zhou, Gaullier and Luger review insights derived from cutting-edge biophysical and structural approaches applied to the study of nucleosome dynamics and nucleosome-binding factors, with a focus on the experimental advances driving the research.
This Review discusses mechanistic insights into 5´–3´ RNA decay, such as translation–decay coupling, coordination between complexes that process 5´ & 3´ RNA termini, conformational control of enzymatic activity, phase separation, & RNA modifications.
Cross-linking mass spectrometry has developed into a robust and flexible tool that provides medium-resolution structural information. This review highlights notable successes of this technique and discusses common pipelines.
In this Review, Haoxing Xu and colleagues summarize current knowledge of TRP channels and their roles in the response to environmental and cellular signals, focusing in particular on the least known class, the organellar TRPs.
Cramer and colleagues review and discuss how the structural elucidation of transcription factors and functional complexes of human mitochondrial RNA polymerase have informed emerging understanding of the mechanism of mitochondrial gene transcription.
Bhat and Cortez discuss current knowledge on the multiple mechanisms by which RPA and RAD51 contribute to genome stability during DNA replication, in particular for replication fork reversal and fork protection.
Developments in basic RNA biology have spawned RNA-based strategies to generate new types of therapeutics. Judy Lieberman reviews RNA-based drug design and discusses barriers to more widespread applications and possible ways to overcome them.
Wu and Wilson review our structural knowledge of influenza virus HA and broadly neutralizing antibodies, which have opened the way for design of novel vaccines and therapeutics.
In this Review, the authors discuss our current understanding of how the hexameric helicases that catalyze helix unwinding during DNA replication are physically and functionally integrated with other replisome components.
In this Review, the authors discuss recent insights into the mechanism of GPCR signaling provided by structural and biophysical elucidation of receptor interactions with G proteins and arrestins.
Rossmann and colleagues review the rapid progress in our understanding of the structure of Zika virus, building on previous studies of other flaviviruses such as dengue virus.
