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John W. 'Jack' Griffin (1942–2011) was the launch Editor-in-Chief ofNature Clinical Practice Neurology, and continued to serve on the Advisory Board after the journal was rebranded as Nature Reviews Neurologyin 2009. In this Essay, the authors pay tribute to Jack, highlighting his seminal contributions to the field of inflammatory neuropathies, and reviewing recent progress in this area, including the emergence of the node of Ranvier as a site of intensive investigation.
