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Researchers in China have developed a functional nucleic acid-based responsive artificial enzyme that enables continuous production of levodopa in a mouse model of Parkinson disease.
A new study indicates loss of hypothalamic melanin-concentrating hormone in ALS, providing insights into the mechanisms underlying weight loss in individuals with the disease.
A new study provides mechanistic insights into the role of TDP43 in regulating the expression of stathmin 2 — a protein that is abundant in motor neurons and is required for axonal regeneration after injury.
According to new research in a mouse model, systemic immune exhaustion could underlie the association between obesity and risk of developing Alzheimer disease.
New research reports changes in serum blood–brain barrier (BBB) markers after bilateral tonic–clonic seizures, corroborating earlier observations in animal models.
A growing understanding of the neurobiology of psychosis offers hope for an improvement in the standard of care; this includes the development of individualized, precision therapeutics. However, the path to precision psychiatry is long, and progress would be accelerated by greater collaboration with the fields of neurology and neuroscience.
Prediction tools offer great promise for clinicians in the prevention and treatment of psychosis, but none has been routinely implemented. Greater methodological rigour in the development and evaluation of these tools, along with consideration of a range of performance criteria, is necessary to maximize their potential for improving clinical decision making.