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  • Recent studies provide new insights into the regulation of lysogeny and prophage induction.

    • Andrea Du Toit
    Research Highlight
  • A recent study finds that upregulation of nutrient-permeable channels in the parasitophorous vacuole membrane increases the acquisition of amino acids by artemisinin-resistant parasites to compensate for fitness costs.

    • Ashley York
    Research Highlight
  • This study provides insights into the neuroinvasive mechanism of neurotropic alphaherpesviruses, which involves viral assimilation and repurposing of a cellular motor protein.

    • Andrea Du Toit
    Research Highlight
  • A recent study provides evidence that the extracellular DNA-based architecture of bacterial biofilms relies on the rare left-handed helical form of DNA known as Z-DNA.

    • Ashley York
    Research Highlight
  • This study shows that segmented filamentous bacteria provide early protection against Citrobacter rodentium via a microbially derived metabolite that primes host innate immunity.

    • Andrea Du Toit
    Research Highlight
  • Two recent studies provide mechanistic evidence that members of the microbiota cooperate to confer colonization resistance against pathogens.

    • Ashley York
    Research Highlight
  • The authors of this study designed a novel therapeutic class of antimicrobials in which they optimized drug binding and permeation of the drug through bacterial membrane transporters simultaneously.

    • Megan Cully
    Research Highlight
  • This study shows that gut bacteria accumulate host-targeted drugs intracellularly, which affects the therapeutic effect of the drug as well as metabolite secretion of the accumulating bacteria without much having an impact on bacterial growth.

    • Andrea Du Toit
    Research Highlight
  • This study demonstrates that commensal bacteria and fungi have opposing roles in the responses of tumours to radiotherapy.

    • Anna Dart
    Research Highlight
  • A recent study finds that the gut microbiota generates diurnal rhythms in innate immune responses that synchronize with host feeding rhythms in mice, allowing the host to anticipate exposure to pathogens.

    • Ashley York
    Research Highlight
  • This study shows that co-existence of the four Lactobacillus species in the gut of the honey bee is mainly dependent on the pollen-rich diet of the host, and mediated by the specialization of the gut symbionts towards distinct pollen-derived nutrients.

    • Andrea Du Toit
    Research Highlight
  • This study reports that bacteriocins are encoded in temperate phages, and that they can be transferred between bacterial hosts, which provides a competitive advantage.

    • Andrea Du Toit
    Research Highlight
  • A recent study finds that sense codon reassignment enables phage resistance and encoded polymer synthesis in Escherichia coli.

    • Ashley York
    Research Highlight
  • This study reports that Vibrio cholerae outer membrane vesicles protect the cholera toxin from degradative enzymes in the intestinal tract and deliver the active toxin to host cells by a porin-mediated mechanism.

    • Andrea Du Toit
    Research Highlight
  • This study analysed environmental growth rates of bacterial predators to study their role in microbial food webs.

    • Ursula Hofer
    Research Highlight
  • This study shows that FtsZ1 and FtsZ2 have different functions during archaeal cell division.

    • Andrea Du Toit
    Research Highlight
  • This study reports that ICEBs1, which is an integrative and conjugative element of Bacillus subtilis, provides a selective advantage to its host cells during two developmental processes: biofilm formation and sporulation.

    • Andrea Du Toit
    Research Highlight
  • This study identifies a cyanobacterial toxin that causes mass mortality of eagles and other birds.

    • Ursula Hofer
    Research Highlight
  • This study reports that antigens derived from intracellular bacteria are presented by tumour cells and activate the immune system.

    • Andrea Du Toit
    Research Highlight