News & Comment

This study reports that an engineered bee symbiont provides protection against Nosema ceranae infection.

The human microbiome has a crucial role in global health, with implications for achieving the Sustainable Development Goals (SDGs). Understanding and harnessing the potential of the microbiome, while recognizing its link to the global ecosystem, can drive innovative strategies for improved public health, and promote sustainable development.

African microbiomes are much neglected and previous studies have disproportionately focused on the Global North. Africa harbours substantial genetic diversity in terms of its ecosystems, humans and animals. In this Comment, we highlight the lack of information regarding microbiome datasets from Africa and propose mechanisms for increasing microbiome research in Africa.

In this study, Fidelle et al. show that recolonization of the gut by Enterocloster spp. after antibiotic treatment compromises the anticancer effect of immune checkpoint inhibitor therapy.

In this study, Catchpole et al. identify the first self-transmissible conjugative plasmid in the euryarchaeon Thermococcus sp. 33-3 and use it to genetically modify diverse hyperthermophilic archaea.

In this study, Vidakovic et al. show that during infection Vibrio cholerae forms biofilms on the surface of human immune cells to kill them and then disperses.

This study shows that healthy individuals are reservoirs for genotypically and phenotypically diverse Candida albicans strains that retain their capacity to cause disease.

This Genome Watch highlights the recent developments of prokaryotic nomenclature leading to the coexistence of two parallel prokaryotic nomenclatural codes.

In this study, Liu et al. demonstrate that the T7SS of the rhizobacterium Bacillus velezensis SQR9 and its effector protein YukE cause iron leakage in plant roots to support root colonization.

This study shows that substrate stiffness has an impact on early microcolony formation.

This study reports a bacterial antiphage protein that contains a NACHT domain, which is also found in metazoan proteins that mediate immunity and inflammation.

This study reports the identification of an inhibitor of a Toxoplasma gondii myosin motor protein that could be exploited to prevent or treat infections with T. gondii and other apicomplexan parasites.

This study reports that the resident panicle microbiota in rice modulates host metabolism to prevent Ustilaginoidea virens infection.

In this study, Brown et al. show that nutrient deprivation increases Plasmodium falciparum survival and tolerance to the antimalarial drug artemisinin.

Shigella spp. that are resistant to almost all antimicrobial classes are increasing in prevalence and becoming globally dominant. The situation is critical and highlights a trend that is mirrored by other enteric bacterial pathogens. New interventions to prevent and treat these infections are essential to tackle a potential public health catastrophe.

In this study, Gencay et al. develop a cocktail of engineered phages to target clinically relevant Escherichia coli strains.

In this study, Tawk et al. explore the impact of infection and inflammation on the adaptations of the commensal population in the mouse gut.

In this study, Carfrae et al. show that inhibition of biotin and fatty acid synthesis restores colistin activity against Gram-negative bacteria and prevents colistin resistance.

This Genome Watch highlights how combining next-generation sequencing and imaging technologies sheds light on the diverse and intricate symbiotic relationships of uncultivated archaea and bacteria.

A recent study reports that uropathogenic Escherichia coli infection triggers trained immunity in urinary tract tissue, which affects the immune response to subsequent infections.