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  • This study shows that intercellular long extensions promote the evasion of antibody neutralization and the efficient intercellular transmission of chikungunya virus in vitro and in vivo.

    • Andrea Du Toit
    Research Highlight
  • This month’s Genome Watch highlights the use of high-depth genome-centric approaches to further our understanding of the human gut microbiome within the context of industrialized and non-industrialized lifestyles.

    • Robert M. Bowers
    Genome Watch
  • This study shows that a gut peptide is active against virulent forms of Candida albicans, thus contributing to the maintenance of fungal commensalism.

    • Andrea Du Toit
    Research Highlight
  • This Genome Watch highlights how the integration of genomic surveillance with epidemiological or clinical data can help understand pathogen transmission and improve public health interventions for infectious disease control.

    • Amber Barton
    • Caroline Colijn
    Genome Watch
  • In this study, Huang et al. discover Delftia tsuruhatensis TC1, a mosquito symbiotic bacterium that inhibits parasite development via the secretion of a small molecule.

    • Agustina Taglialegna
    Research Highlight
  • In this study, Sharafutdinov et al. report a single nucleotide polymorphism in the gene encoding the HtrA protease of Helicobacter pylori that is associated with gastric cancer.

    • Agustina Taglialegna
    Research Highlight
  • The forthcoming UN summit marks the halfway point to 2030 and presents an important milestone in global efforts to address various challenges, including those related to climate change and environmental preservation. The UN SDGs include several related to microorganisms and climate change. Microbiology research is key to understanding and mitigating climate change, and in maintaining the health of terrestrial and aquatic ecosystems (SDGs 13, 14 and 15).

    • Janet K. Jansson
    Comment
  • This study shows that Haloferax volcanii uses its type IV pili for cell attachment to a surface and mechanical cohesion between cells under flow conditions, thus promoting biofilm development.

    • Andrea Du Toit
    Research Highlight
  • Infectious diseases markedly influence progress towards the SDGs. Pandemics and global inequity have hindered progress towards the health targets, highlighting humanity’s interconnectedness and shared vulnerability to new infectious agents. Enhanced global collaboration and partnerships in training, surveillance, research and innovation are essential to reach the health SDGs by 2030.

    • Quarraisha Abdool Karim
    • Salim S. Abdool Karim
    Comment
  • In this study, Gül et al. show that usage of different carbon sources by Enterobacteriaceae strains determines their expansion and co-existence in the mouse gut and favours plasmid transfer.

    • Agustina Taglialegna
    Research Highlight
  • The study reveals how a satellite phage-encoded protein directs the assembly of coat proteins into small capsids.

    • Andrea Du Toit
    Research Highlight
  • In this study, Tsuji et al. report the glycolipid 7DW8-5 that exploits the host innate immune system to control SARS-CoV-2, respiratory syncytial virus and influenza virus infections.

    • Agustina Taglialegna
    Research Highlight
  • The authors developed a refillable, long-acting subcutaneous nanofluidic antiretroviral delivery implant that conferred protection against infection with simian–human immunodeficiency virus in rhesus macaques.

    • Andrea Du Toit
    Research Highlight
  • In this study, Douglas et al. examine the role of the staphylococcal TcaA protein in human serum susceptibility during bacteraemia.

    • Agustina Taglialegna
    Research Highlight
  • In this study, Irazoki et al. show that Vibrio cholerae releases d-amino acids into the environment, which are sensed by a bacterial chemoreceptor to prompt a repellent chemotactic response.

    • Agustina Taglialegna
    Research Highlight
  • This study provides insights into the mechanism whereby Citrobacter rodentium transitions from the intestinal lumen to its mucosal niche.

    • Andrea Du Toit
    Research Highlight
  • This Genome Watch highlights new computational approaches aimed at circumventing contamination in low-biomass microbiome studies.

    • Yan Shao
    Genome Watch
  • This study suggests that pre-existing DENV immunity has a negative effect on the pathogenesis of secondary ZIKV infection during pregnancy in marmosets.

    • Andrea Du Toit
    Research Highlight
  • This study reveals the conformational changes of the utilisome that facilitate glycan processing and import.

    • Andrea Du Toit
    Research Highlight