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    • This Review discusses the complex mechanisms of wound healing — cell migration, matrix remodelling, inflammation and angiogenesis — and the contributions of different cell types, including immune cells, to this process. It also highlights new methodologies that could inform future therapies to prevent scarring and repair chronic wounds.

      • Oscar A. Peña
      • Paul Martin
      Review Article
    • Methodological advances have enabled discoveries of RNA polymerase interactions with RNA processing machineries, such as the splicing and 3′-end cleavage machineries. This Review discusses the roles of these interactions in gene regulation and eukaryotic cellular stress responses, and highlights parallels between co-transcriptional RNA processing in eukaryotes and prokaryotes.

      • Morgan Shine
      • Jackson Gordon
      • Karla M. Neugebauer
      Review Article
    • Somite formation, crucial for organization of the segmental pattern of vertebrate embryos, depends on the oscillatory expression of segmentation clock genes. Novel in vitro models of somitogenesis have provided insights into the spatiotemporal dynamics of gene expression, signalling and metabolic gradients that enable somite formation and patterning.

      • Yuchuan Miao
      • Olivier Pourquié
      Review Article
    • Gene regulation in animals depends chiefly on enhancers, yet the underlying mechanisms are poorly understood. This Review discusses enhancer–promoter interactions and transcription activation, focusing on how enhancer–promoter selectivity is achieved and on recent technical advances that may provide new insights into transcription activation.

      • Jin H. Yang
      • Anders S. Hansen
      Review Article
    • The prevailing challenge in live-cell fluorescence microscopy is capturing intra-cellular dynamics while preserving cell viability. Alongside developments of microscopy hardware, computational methods — especially those based on machine learning — are powerful tools to improve the signal-to-noise ratio, spatial resolution, temporal resolution and multi-colour capacity of live-cell imaging.

      • Hari Shroff
      • Ilaria Testa
      • Suliana Manley
      Review Article
  • In this Tools of the Trade article, Venkova and Popard (Piel lab) discuss recent updates to the fluorescence exclusion method that now enable simultaneous measurement of cellular and nuclear size as well as investigation of small prokaryotic cells.

    • Larisa Venkova
    • Henri Popard
    Tools of the Trade
  • Ahna Skop and Karen Schindler describe a paper that found localized translation in mammalian embryos, demonstrating the importance of RNA transport for development.

    • Ahna Skop
    • Karen Schindler
    Journal Club
  • The story of a paper that established the concept of codon optimality and its connection with translation efficiency and mRNA decay.

    • Susanne Bornelöv
    Journal Club
The sea with lipid rafts

Lipids and membranes

This article series brings together Reviews that focus on key advances in understanding membrane biology as well as the regulation and functions of their lipid components, including their roles as bioactive molecules and their interplay with metabolism.
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