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Gary Koretzky, who was president of the American Association of Immunologists from 2021 to 2022, shares his thoughts on the responsibility of scientists to make science more accessible to a broad public, and reflects on lessons learned during the pandemic.
In this Tools of the Trade article, Leanne Arakkal (of the Ronald Germain group) describes a technique for highly multiplexed imaging of intact tissues.
Drugs that target protein kinases have had a major impact on the treatment of cancer and now are proving beneficial in numerous immunological diseases. This Review describes their clinical application, with a focus on Janus kinase inhibitors, and how they inform mechanisms of disease and have evolved to improve efficacy and safety.
Here, Schenkel and Pauken consider how specific patterns of T cell trafficking and localization in tissue microenvironments shape their immune functions in acute infection and cancer settings. They further consider the relevance of this for the efficacy of immune checkpoint blockade therapy in the clinic.
Fifty years since the discovery of HMGB1 protein, its physiological and pathological roles have been extensively studied. This Review covers the structure, localization and functions of HMGB1 in immune responses, including historical foundations and recent advances.
Regulatory T cells (Treg cells) are controlled by a raft of transcription factors besides Forkhead box protein 3 (FOXP3). As detailed in this Review, these accessory transcription factors act alone or together with FOXP3 to coordinate Treg cell specification and function, and account for heterogeneity of niche-specific Treg cells.
