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Volume 25 Issue 2, February 2024

Inspired by the Review on p83.

Cover design: Patrick Morgan.

Research Highlights

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Journal Club

  • Li Zhao recalls a 2006 paper by Levine et al. that, by identifying a handful of de novo genes, outlined a potentially universal process of de novo gene birth and propelled forward this field of research.

    • Li Zhao
    Journal Club
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Reviews

  • Ancient DNA studies over the past decade have yielded a plethora of insights into the Denisovan archaic hominin group. The authors review our understanding of Denisovan population history and their interactions with other human groups, insights from studies of Denisovan ancestry in modern humans, what we know about the Denisovan phenotype and their impact on our own evolutionary history.

    • Stéphane Peyrégne
    • Viviane Slon
    • Janet Kelso
    Review Article
  • Native nucleotide modifications regulate RNA function and metabolism, the study of which has revealed disease mechanisms, offers therapeutic potential and enables innovative clinical strategies. Chemical modifications in RNA are harnessed for clinical use in stable artificial RNAs such as mRNA vaccines and synthetic small RNA molecules.

    • Sylvain Delaunay
    • Mark Helm
    • Michaela Frye
    Review Article
  • Antimicrobial resistance (AMR) is an important public health issue that affects human, animal and environmental sectors worldwide. The authors review the role of genomics in AMR surveillance using a One Health approach, and how genomic approaches can help mitigate the spread of AMR to improve global health.

    • Steven P. Djordjevic
    • Veronica M. Jarocki
    • Benjamin P. Howden
    Review Article
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