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Rubin et al. report the development of a programmable organism- and locus-specific genome editing approach that can target microorganisms in their native community context, without the need for isolation.
A study in Science reports the genetic determinants of differences in immune responses to viral infection between individuals of European and African ancestries.
A study in Nature Communications shows that horizontal transfer of bacterial chromosomes by phage-mediated lateral transduction renders them more mobile than many classically defined mobile genetic elements, including plasmids and transposons.
A study in Cell describes how non-coding RNAs can drive the formation of higher-order RNA-chromatin structures in the nucleus, with a role in mediating chromatin conformation and gene expression.
Two recent studies demonstrate that putative nucleases encoded by IS200/IS605 family transposons are programmable RNA-guided DNA endonucleases, which could represent a new source of genome-editing enzymes for biotechnological applications.
A study in Nature Biotechnology describes single-cell genome and epigenome by transposases sequencing (scGET-seq), which generates euchromatin and heterochromatin profiles from the same cell, and Chromatin Velocity, a computational framework capable of predicting future epigenetic cell fate trajectories from scGET-seq data.
A study in Nature describes single-cell ribosome sequencing, which advances single-cell genomics by enabling the measurement of translational dynamics in single cells.
Three recent studies report the generation of miniature CRISPR systems based on compact Cas effector proteins, showing high efficiency of genome editing or transcriptional regulation in mammalian cells.
Four new studies in Nature report multi-tissue analyses of somatic mutations from human donors, with insights into cell lineage commitment during embryonic development, as well as tissue-specific aspects of mutagenesis.
This molecular phenotyping study shows that common variants in mitochondrial DNA associated with diseases of ageing influence cellular protein homeostasis, and that this link is mediated by circulating levels of N-formylmethionine, the initiating amino acid in mitochondrial protein synthesis.
A new study in Nature reports a large-scale genome-wide association study of menopause timing, revealing mechanistic details and potential therapeutic opportunities for preserving human fertility.
Attempts to understand the role of aneuploidy in tumorigenesis have been hampered by conflicting results. Now, two new mouse models described in Genes and Development provide evidence that chromosome instability-induced aneuploidy drives T cell lymphomagenesis.
Capturing rare protein-coding variation by whole-exome sequencing in large and diverse population samples can help identify large-effect associations and drug targets, suggest two recent publications.
A new study by Ahn et al. shows that chimeric proteins containing intrinsically disordered regions mediate oncogenesis by inducing liquid–liquid phase separation and thereby affecting chromatin conformation and transcription.
A study in Cell describes the discovery of a conserved set of small non-coding RNAs that are glycosylated in diverse cell types. These glycoRNAs are found at the surface of cells, where they can participate in extracellular interactions.
Two studies report the successful application of CRISPR adenine base editors for in vivo genome editing of a disease-related gene in non-human primates.
The Vertebrate Genomes Project, which aims to produce high-quality reference genomes for all 71,657 living and named vertebrate species, reports the generation of high-quality genome assemblies for the first 16 species and describes the biological findings that these genomes have informed.
A new study in Science reports the extraction and analysis of ancient hominid nuclear DNA from Paleolithic sediments. This advance paves the way to a fuller picture of human evolution by bypassing the dependency on rare skeletal remains.
Xia et al. highlight an unexpected horizontal gene transfer event, whereby the sweet potato whitefly has harnessed a host plant detoxification mechanism to resist its defences.
