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In a study in Nature Microbiology, Setoh et al. use deep mutational scanning to speed up viral evolution and identify key determinants of host tropism in Zika virus.
A study in Nature reveals that N6-methyladenosine (m6A) modification of RNA occurs co-transcriptionally and is mediated by interactions between histone H3 lysine 36 trimethylation (H3K36me3) and the m6A methyltransferase complex.
Nair et al. contrast events at specific super-enhancers after acute and chronic ligand-induced activation and show that biomolecular condensates at these enhancers undergo physical changes over time that affect chromatin conformation and gene expression.
Two studies in Science show that cytosine base editors, but not adenine base editors or CRISPR–Cas9, induce notable off-target single-nucleotide variants in rice and in mouse embryos.
Chromosomal inversions that relocate a limb enhancer establish patterns of asymmetric chromatin contacts, so-called architectural stripes, that result in ectopic gene expression and congenital limb phenotypes, according to a study in Nature Cell Biology.
A new technique named ChIA-Drop combines chromatin interaction analysis (ChIA) with droplet-based and barcode-linked high-throughput sequencing to capture multiplex chromatin interactions at the single-molecule level.
A study published in Nature reports the functional and structural characterization of CasX, an RNA-guided DNA endonuclease with potential for use as a new genome editing platform.
A new study uses deep learning to predict genetic variants that generate cryptic splice sites and to investigate the role of these non-coding cryptic splice mutations in rare genetic disorders.
Two studies in Developmental Cell report the generation of mice with longer and shorter than normal tails, respectively, giving insight into developmental programmes and key genes involved in mouse tail development.
A new study published in Cell uses bacterial genetic screens to identify mutagenic proteins. Overexpression of homologues of these proteins in human cells has similar mutagenic effects and potential prognostic value in cancer.
The BabySeq project, a pilot randomized clinical trial exploring the value of routine genomic sequencing of neonates compared with standard newborn screening, now reports initial results in the American Journal of Human Genetics.
