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Case studies of patients with anorexia nervosa revealed psychological improvements upon treatment with recombinant human leptin, including an alleviation of the entrapment in this eating disorder. Hypoleptinaemia induced by loss of adipose tissue mass might trigger psychological changes observed in starvation. Accordingly, leptin analogues might prove beneficial for treatment of anorexia nervosa.
Type 2 diabetes mellitus is a progressive disease requiring regular monitoring and therapeutic changes. It is important that healthcare professionals embrace both ends of the spectrum of therapeutic inertia, including appropriate advancement and de-intensification of therapies.