Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
Up to one-third of cancers are due to excess weight and insufficient physical activity. What mechanisms are involved and can physical activity interventions reduce cancer risk?
The family of glycophosphoproteins known as small integrin-binding ligand N-linked glycoproteins (SIBLINGs) are emerging as important players in malignant transformation, invasion and metastasis. Could these proteins be promising diagnostic and prognostic tools, as well as therapeutic targets?
Tumour responses to treatment are still largely assessed from imaging measurements of reductions in tumour size, which can take weeks to be manifest. This Review presents the new non-invasive techniques that can give early evidence of tumour response.
Cancer cells survive despite violating rules that ordinarily provoke apoptosis. Now that we understand more about how members of the BCL2 family of proteins regulate apoptosis, can we exploit our knowledge to more effectively target cancer cells?
The tumour suppressor FBW7 is the substrate recognition component of the SCF-type ubiquitin ligase that degrades several proto-oncogenes, including MYC and cyclin E. How do the numerous cancer-associated mutations inFBW7and its substrates contribute to tumorigenesis?
DNA vaccines against cancer allow a high degree of molecular precision, but until recently translation into the clinic has been difficult. Advances in delivery techniques are now allowing them to fulfil their potential.
The Ras-family G-proteins RALA and RALB seem to be key offenders in the subversion of core biological systems driving oncogenic transformation. This up-to-date Review focuses on current developments within this field.
The receptor tyrosine kinase anaplastic lymphoma kinase (ALK) was first identified as part of a chromosomal translocation associated with some anaplastic large cell lymphomas (ALCLs). Now data are emerging that indicate that ALK might be a valid therapeutic target in ALCL and that it could also be involved in other cancers.
Thiopurines are effective anti-inflammatory, anticancer and immunosuppresive drugs. However, azathioprine is also a carcinogen. So, how do thiopurines exert their therapeutic and carcinogenic effects?
High-dimensional genomic and proteomic data are now commonplace in cancer research. This Review aims to help biologists understand the properties of high-dimensional data spaces and how these affect our ability to derive meaningful information from the data.