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Cancer patients often experience cognitive changes after chemotherapy (sometimes called “chemo brain”). What are some possible molecular mechanisms for this detrimental side effect of cancer therapy?
The Salvador–Warts–Hippo (SWH) pathway is involved in tissue growth control in Drosophila melanogaster. There is increasing evidence that deregulation of this conserved pathway occurs in human tumours. What insights do the studies in Drosophila provide for human carcinogenesis?
Transient protein–protein interactions occur in many cellular processes that are implicated in cancerous growth, such as cell-cycle transitions mediated by the cell division cycle 25 phosphatases. What are the issues that are encountered when considering these transient interactions as drug targets?
G-protein-coupled receptors (GPCRs) influence many steps in tumorigenesis, including proliferation, survival, angiogenesis, metastasis and evasion of the immune system. This Review provides an overview of the various roles of GPCRs in cancer and their potential as therapeutic targets.
The term myelodysplastic syndromes covers various diseases that are caused by ineffective haematopoiesis in one or more lineages of the bone marrow. How do these diseases arise, and what are the best methods for treating these patients?
Monoclonal antibodies (mAbs) that regulate the immune response are now being clinically evaluated as anticancer agents. This Review discusses their progress to date and the possibilities for combining these antibodies with other cancer treatments.
A new generation of promising anti-mitotic therapies that target proteins with specific functions in mitosis has been developed. As these drugs enter phase I and II trials, what do we know about their mechanism of action and their therapeutic range, and which patients will benefit?
The identification of high-risk human papillomavirus types as a necessary cause of cervical cancer offers the possibility of improving cervical cancer detection and prevention. What uncertainties need to be clarified for these possibilities to be realized?
