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This Review discusses intra-prostatic inflammatory processes and how they are induced and perpetuated, thereby driving prostate cancer development and progression. By discussing external inflammatory cues in connection to cancer cell-intrinsic factors in prostate tumorigenesis, the authors provide insight into potential preventative and therapeutic strategies.
This Review presents the evidence for the role of risk factors in breast cancer incidence and their inclusion in risk estimation tools as a step towards precision prevention to specifically target those women at increased risk for appropriate risk-reducing interventions.
This Review discusses recent advances in cohesin biology in cancer, providing insights into the role of cohesin inactivation in cancer pathogenesis and opportunities for exploiting these findings for the clinical benefit of patients with cohesin-mutant cancers.
This Review outlines the ways in which leukaemic stem cells (LSCs) take advantage of normal haematopoietic stem cell properties to promote survival and expansion in myeloid leukaemogenesis. Opportunities for treatment of this disease by targeting LSC-specific mechanisms are also discussed.
This Review discusses oncoproteins known to cause both cancer and congenital disorders, and the biology of oncoproteins in both transformed and untransformed tissues, exploring the fundamentals of genetics, signalling and the pathogenesis that underlie oncoprotein duality.
After synthesis, all RNA molecules are subject to covalent modifications. This Review presents the evidence that RNA modification pathways are misregulated in cancer and suggests that they may be ideal targets for cancer therapy.
Peripheral T cell lymphomas (PTCLs) are a heterogeneous group of rare neoplasms. This Review outlines our current understanding of the genomic defects and host environment characteristics that promote PTCL development with the aim of improving molecular stratification and targeted therapy for PTCLs.
This Review outlines the recent advances in the creation of both combinatorial transgenic cancer models in zebrafish and zebrafish patient-derived xenograft models, and argues that these models have potential to be used as avatars for precision oncology.
This Review focuses on the role of tumour cell-autonomous signalling after radiotherapy. It describes how radiotherapy, through its immunomodulating effects, might be combined with immune checkpoint inhibitors and other immunotherapies and how DNA damage response inhibitors in combination with radiotherapy may be used to further augment this approach.
Recent single-cell RNA-sequencing studies have revealed a range of intratumoural T cell states, both within and between patients. This Review outlines the CD8+ T cell states that have been identified in human tumours and the potential roles they play in tumour control as well as how they are influenced by immune checkpoint blockade.
This Review discusses the role that nerves play in the initiation and progression of cancers, focusing on the evidence that tumours may reactivate nerve-mediated developmental and regenerative pathways to promote their own growth and survival.
This Review discusses many of the similarities and differences between leukaemia stem cells (LSCs) in chronic myeloid leukaemia and acute myeloid leukaemia and examines the therapeutic strategies that could be used to eradicate these LSCs.
