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A series of techniques (echocardiography, novel object recognition, grip strength, rotarod, glucose and insulin tolerance tests, body composition, and energy expenditure) are used to assess the health of mice.
Functional mouse hematopoietic stem cells (HSCs) are expanded 236- to 899-fold ex vivo using a fully defined albumin-free culture system. Clonal analysis of HSC heterogeneity and HSC transplantation are also described.
This protocol manipulates the hydrophobicity of DNA and tailors its conformation at the water–oil interface on an organogel surface. Measuring the sliding speed or the critical sliding angle offers a droplet motion-based biosensing platform for the visual detection of small molecules, nucleic acids and proteins.
Here, the authors present standardized computational pipelines tailored specifically to the analysis of cancer genome sequencing data from mice. The protocol enables detection of single-nucleotide variants, indels, copy-number variations, loss of heterozygosity and complex rearrangements such as those of chromothripsis.
