Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
DNA-origami nanostructures self-assembled at milder physicochemical parameters in magnesium-free conditions achieve structural complexities akin to those formed by thermal annealing at elevated temperatures, and open a route to assembling DNA nanomachines in physiological conditions.
By integrating a 3D nanopositioner with a solid-state nanopore and surface-tethered molecules, precise spatiotemporal control over single DNA strands is achieved, enabling numerous re-reads and raising the signal-to-noise ratio far beyond previous solid-state nanopore methods.
Neuromorphic photodetectors are typically volatile and/or complex with multiple gates, leading to reduced energy efficiency for intelligent perception applications. Two-terminal MoS2 photodetectors have now been developed in which electrically driving the migration of sulfur vacancies enables dynamic modulation of the Schottky barriers and the realization of reconfigurable and non-volatile responsivities.
A sudden inversion of the supercurrent diode effect is revealed in both inductance and critical current measurements in ballistic Josephson junctions. A simple analytical model shows that the inversion is associated with a ground state jump, the elusive 0−π-like transition.
Spintronic nano-neurons and synapses can be connected by radiofrequency signals into neural networks that are capable of classifying real-world radiofrequency inputs without digitization at high speed and with low energy costs—an important step for artificial intelligence at the edge.
The development of flexible thermoelectrics is limited by the low power factor and brittleness of materials. Here the authors present strategy to turn Bi2Te3-based single crystals into flexible films with staggered-layer structure while maintaining superior thermoelectric performance.
Interaction of two-dimensional transition metal dichalcogenide grains with exposed oxygen–aluminium atomic plane in sapphire is a more dominant factor than step-edge docking in controlling the single-crystal epitaxy of these materials.
Surface chemistry controls the location of WSe2 nucleation on a stepped sapphire substrate. Preferential nucleation at either the top or bottom step edge can be used to minimize mirror twin domains and produce unidirectional WSe2 monolayers.
A neuromorphic photovoltaic detector with highly tunable responsivity and simultaneous non-volatile storage of image data has been demonstrated in a neural network, representing a transformative leap in the compactness and function of visual perception hardware.
In contrast to conventional thermal annealing approaches, the authors report on the self-assembly of complex mixtures of DNA at room or physiological temperature for generating user-defined programmable nanostructures capable of shape selection and transformation.
A synthetic nanocarrier based on DNA origami chassis offers control over valency, orientation and spatial arrangement of antibodies for simultaneously engaging immune signalling pathways, checkpoint inhibition and targeted co-stimulation in anticancer immunotherapy in vivo.
Protein-based nanobiosensors with two epistatically interacting synthetic allosteric regulatory systems result in YES gate protein switches with large dynamic ranges and fast response times. These biosensors enable construction of rapid diagnostic tests compatible with clinical chemistry analysers.
Electro-osmosis in an anion-selective α-hemolysin nanopore is used to capture, unfold and transport polypeptides of over 1,200 residues, which allows the mapping of post-translational modifications in polypeptide chains by monitoring the ionic current at a single-molecule resolution.
PEGylated liposomal accumulation in inflamed regions has mainly been attributed to the enhanced permeation and retention effect. An arthritis model that chemotactically attracted myeloid cells shows that monocytes and neutrophils play an essential role in liposome delivery towards inflamed joints.
STING agonists are often limited by low circulation time and cellular uptake. The conjugation of STING agonists with polymer nanoparticles is shown to enhance stability, circulation time and cellular uptake, increasing the immunotherapeutic activity.
Overcoming the immunosuppressive tumour microenvironment is a challenge. A strategy to close the cancer–immunity cycle has been reported by integrating lipid nanoparticle–mRNA formulations and dendritic cell therapy to promote tumour elimination and develop antitumour immunity.
