Volume 17 Issue 3, March 2022

Controllably buckling an array of vertical field effect transistors enables intracellular electrophysiological mapping with high spatial and temporal resolutions.

Examining nucleic acid delivery in humanized animal models might accelerate nanoparticle optimization and potentially improve clinical translation strategies.

Tiny quantities of heat delivered on demand by discrete quantum excitations expand the horizon of quantum electrical metrology.

This Review discusses the recent progress in the emerging field of exciton phenomena in semiconductor moiré superlattices.

Hybrid single-electron turnstiles are candidates as a standard for the ampere expressing it with elegant simplicity. Yet, such devices may serve as a standard for the watt with similar elegance and simplicity.

The movement of fractionalized phase defects, that can be considered as fractional solitons promising for future information technology, is observed in atomic chains formed along step edges of silicon surfaces, solitons may serve as robust, topologically protected information carriers in future information technology

Holographic vector-field electron tomography reveals the three-dimensional magnetic texture of Bloch skyrmion tubes in FeGe at nanometre resolution, including complex three-dimensional modulations and fundamental skyrmion formation principles.

A cryo-strain device capable of applying large, continuous strains to two-dimensional materials in situ enables the reversible tuning of magnetic order and spin-canting process of the layered magnetic semiconductor CrSBr.

The implementation of parity–time symmetry in a complementary metal–oxide–semiconductor process technology enables the realization of wide-band high-quality microwave generation and broadband strong microwave isolation at gigahertz frequencies.

Beta-alumina solid electrolyte enhanced by yttria-stabilized zirconia can provide a very low interfacial impedance with a sodium metal anode and a critical current density higher than those previously reported in lithium and sodium batteries.

A non-destructive soft-lock drawing method can achieve carbon nanotube arrays with ultraclean surfaces and a very high degree of alignment. Such arrays could be used as nano-sized electrical contacts of high-density monolayer MoS₂ transistors.

A growth strategy based on surface-accumulated excess electrons enables the realization of non-oxidized bare copper nanoparticles stable under ambient conditions.

A three-dimensional field-effect transistor array produced via compressive buckling enables accurate and minimally invasive intra- and intercellular recordings in cells and cellular networks.

Flexible neural probes, consisting of a linear array of graphene microtransistors, can be used to record from DC brain signals to high-frequency neuronal activity in awake rodents, thus showing potential for in vivo electrophysiology, and in particular epilepsy research.

The extent to which mRNA delivery, as well as the cellular response to mRNA drug delivery vehicles, is conserved across species in vivo is unknown. Using species-independent DNA barcoding, the authors measure delivery in humanized, primatized and normal mice, and identify a potential mechanism driving species-dependent lipid nanoparticle delivery.

Orally delivered rapamycin is an immunosuppressant that inhibits islet graft rejection in patients treated for type 1 diabetes, but it suffers from poor bioavailability, inconsistent cellular distribution and adverse reactions. Here the authors show that subcutaneous delivery of rapamycin using a polymersome platform allows for control of the drug’s biodistribution and activity on specific immune cells, which changes its mechanism of action from immunosuppression to tolerance, reduces side effects and enhances anti-inflammatory efficacy.