Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
A three-dimensional field-effect transistor array produced via compressive buckling enables accurate and minimally invasive intra- and intercellular recordings in cells and cellular networks.
Beta-alumina solid electrolyte enhanced by yttria-stabilized zirconia can provide a very low interfacial impedance with a sodium metal anode and a critical current density higher than those previously reported in lithium and sodium batteries.
Flexible neural probes, consisting of a linear array of graphene microtransistors, can be used to record from DC brain signals to high-frequency neuronal activity in awake rodents, thus showing potential for in vivo electrophysiology, and in particular epilepsy research.
The movement of fractionalized phase defects, that can be considered as fractional solitons promising for future information technology, is observed in atomic chains formed along step edges of silicon surfaces, solitons may serve as robust, topologically protected information carriers in future information technology
Holographic vector-field electron tomography reveals the three-dimensional magnetic texture of Bloch skyrmion tubes in FeGe at nanometre resolution, including complex three-dimensional modulations and fundamental skyrmion formation principles.
Malignant pleural effusion (MPE) is the terminal stage of cancer and the current standard of care for MPE is largely palliative. Here the authors design a liposomal nanoparticle loaded with cyclic dinucleotide for targeted activation of STING signalling in macrophages and dendritic cells and show that, on intrapleural administration, the nanoparticle effectively mitigates the immune cold MPE and significantly augments the checkpoint blockade immunotherapy in a mouse MPE model and clinical patients’ samples.
A strategy based on molecular intermixing of two highly miscible components enables the demonstration of high efficiency multiple-component organic solar cells.
Square-centimetre scale, multilayer superlattice structures based on atomically thin two-dimensional chalcogenide monolayers enable the realization of excitonic metamaterials.
A general versatile approach combining wet-chemistry impregnation and two-step annealing is devised for the scalable synthesis of a library of ultra-high-density single-atom catalysts with drastically enhanced reactivity.
Light-induced contraction in the out-of-plane direction in two-dimensional (2D) hybrid perovskites enables the realization of high-efficiency 2D perovskite solar cells.
A study of gold nanospheres and nanorods shows that, even without internalization, they are very efficient for siRNA delivery and inducing gene silencing in mature plant leaves.
Photoluminescence blinking is a ubiquitous phenomenon that detrimentally reduces emission stability and quantum yield. Now, an all-optical method, which employs ultrafast mid-infrared pulses, can effectively suppress the blinking of single CdSe/CdS core–shell quantum dots.
A combination of quantitative optical spectroscopic techniques and synchrotron nanoprobe measurements enable a visualization of the nanoscale chemical, structural and optoelectronic landscape in halide perovskite devices.
De novo designed peptide with β-hairpin structure assembles to form a β-barrelled nanopore that can detect not only polynucleotides but also polypeptide chains at a single-molecule level.
Diodes exhibit non-reciprocal current–voltage relations, that is, the resistivity depends on the direction of the current flow. Now an array of Josephson junctions with large spin–orbit interaction acts as the superconducting version of a diode, where dissipation-free supercurrent flows in one direction, but not the other.
Neutrophils are the first responders in acute inflammatory events such as acute respiratory distress syndrome and tend to home to lung capillaries during acute inflammation, where they can cause tissue damage by diapedesis and secretion of specific molecules. Here the authors show that nanoparticles coated with agglutinated proteins selectively target activated neutrophils in inflamed lungs and can be used for imaging and therapeutic purposes.
Cancer cells adopt a series of strategies to evade the immune response mounted by the organism against them. Here we find that tumour cells can hijack mitochondria from immune cells by forming physical nanotubes, and suggest that inhibiting this process might represent a potential immunotherapy approach.
Innate immune cells such as dendritic cells and macrophages can activate the adaptive immune system against cancer by presenting cancer-specific antigens, although this activity is severely limited in macrophages due to their intrinsic lysosomal cysteine protease activity. Here the authors show that a DNA nanodevice specifically targeted to macrophage lysosomes can inhibit cysteine proteases in these cells, restoring their antigen-presenting capability.