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A Perspective discussing the factors that have contributed to the success and failure of point-of-care tests for resource-limited settings and the challenges and opportunities that exist for developing new infectious disease diagnostics.
This Perspective argues that microbiome research needs to consider the different philosophical definitions of function to avoid confusion in the field, and uses the hologenome concept as an example.
The colonization resistance paradigm is explored, with a focus on the benefits and limitations of current murine models used to assess the role of the microbiota in enteric infection.
