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Comparative RNA-seq, ChIP–seq and quantitative phosphoproteomics reveal how the blast fungus uses the Pmk1 MAP kinase to regulate a network of transcription factors that orchestrate the complex transcriptome changes necessary for infecting rice plants.
Analysis of the archaeal gut microbiota of 110 vertebrate species spanning five taxonomic classes revealed that host phylogeny could explain archaeal diversity.
Ancestral avian influenza A viruses are used to identify adaptive changes in viral polymerase and nucleoproteins that enable efficient replication and transmission in pigs.
Cryo-electron microscopy and cryo-electron tomography reveal conformational changes of the bluetongue virus capsid protein VP5 that lead to membrane perforation and virus release into the cytosol.
A genome-wide Tn-seq analysis of the rpoB H526Y mutant, a rifampicin-resistant Escherichia coli strain, identifies non-essential genes that modulate the fitness cost of mutations in the bacterial RNA polymerase that confer antibiotic resistance.
Viral encephalitis caused in mice by La Crosse arbovirus can be treated with rottlerin, which prevents viral trafficking from the Golgi and reduces virus titres and neuronal cell death in the central nervous system.
Bifidobacterium species associated with breastfeeding can convert aromatic amino acids into their respective aromatic lactic acids via a previously uncharacterized aromatic lactate dehydrogenase, which may impact immune function in infants.
The authors assess the durability and long-term cross-reactivity of neutralizing antibodies raised in response to infections with SARS-CoV-2 or variants of concern in humans.
A prospective, cross-sectional survey of 12,572 participants in Ethiopia reveals that malaria diagnostics miss almost 10% of cases owing to a gene deletion in Plasmodium falciparum that is under positive selection.
Flies, insects and spiders can serve as vectors of multidrug-resistant Enterobacterales in a public hospital in Pakistan, according to a clinical and molecular epidemiology study.
In this Article, the authors perform evolutionary analyses of M. abscessus clinical isolates and report the emergence of dominant circulating clones (DCCs) in non-cystic fibrosis (CF) individuals followed by amplification in the CF community.
Staphylococcus aureus pathogenicity islands are not all equal and can be satellites of pathogenicity islands or satellites of helper phages in a beguiling regulatory triad that enables pathogenicity island transfer.
In Bangladesh, genomics, social media and mobile phone data streams are integrated to map the spread of SARS-CoV-2 lineages and inform country-level policies to curb infection rates.
Analysis of lower respiratory tract microbiome of mechanically ventilated COVID-19 patients rules out a role for secondary respiratory infections as drivers of increased mortality.
Transposon directed insertion–site sequencing (TraDIS) is used to identify T6SS toxins in Pseudomonas aeruginosa, leading to the discovery of Tse8 as a protein that is delivered to target cells where it alters the stoichiometry of the transamidosome complex and thereby inhibits protein synthesis.
Evolution of the SARS-CoV-2 spike protein receptor-binding domain in vitro recapitulates SARS-CoV-2 variant emergence and produces an effective antiviral spike receptor-binding domain variant.
Malaria parasites are protected from febrile temperatures in humans by a heat-shock response that is coordinated by the transcriptional activator PfAP2-HS.
In this Article, the authors identify CcrZ as a protein that coordinates DNA replication and cell division in Streptococcus pneumoniae and other Firmicutes. CcrZ is localized to the division site by binding directly to the divisome protein FtsZ, and there it activates DnaA, the master initiator of DNA replication, through a still unknown mechanism.
Host preferences of commensal bacteria in the root microbiota are revealed using systematic analyses of synthetic bacterial communities in a gnotobiotic system.