News & Comment

Increasing the sensitivity of DNase-seq allows chromatin accessibility to be profiled from very low numbers of cells.

Cells are under mechanical tension in their native environment. New genetically encoded tension sensors can make a broader range of these forces visible.

Engineered Jedi T cells scour the body to eliminate GFP-expressing cells.

A map of mammalian protein interactions highlights the importance of substoichiometric interactions.

Ultrafast ultrasound microscopy allows for super-resolution ultrasound imaging of vasculature in whole organs.

The small, single RNA–guided nuclease Cpf1 is active in human cells.

Researchers develop an approach based on solid-state nuclear magnetic resonance (NMR) to study the structure of an intrinsically disordered protein under near-native conditions.

Functional magnetic resonance data are traditionally analyzed on a population level, but new work shows that meaningful information can be extracted from individual subjects.

A nanopore used for sequencing gives a detailed view of how motor proteins behave on DNA.

Spatially targeted optical microproteomics identifies novel amyloid plaque components.

Researchers report that the illumination intensities used in super-resolution imaging can irreversibly damage live cells.

An alternative to optogenetics, sonogenetics uses ultrasound to mechanically stimulate neurons.

A new probe allows for optical erasure of newly activated dendritic spines.

A systematic analysis of protein-complex composition across a billion years of evolution reveals a spectrum of conservation.

Two strategies improve structured illumination microscopy for use in live-cell super-resolution imaging.

Two computational tools find residues that determine the specificity of any kinase and the effects of mutations in these residues on the phenotype of cancer cells.

Two computational tools extract strain-level information from reams of microbial sequence data.

Proximity ligation allows for the global resolution of RNA secondary structures.

Fusing ribosomal subunits provides answers to basic questions about their function and opens the door to exciting engineering possibilities.

Fluorescent labeling of bacteria enables tracking of their location.