News & Comment

At last, a method to measure long-range vibrations in proteins may provide clues to the functional relevance of these motions.

Background removal greatly improves localization microscopy performance.

A small peptide–based method knocks down native proteins in vitro and in vivo.

A new device for injecting membrane-protein microcrystals into the path of an X-ray free-electron laser beam improves the efficiency of serial femtosecond crystallography.

Protein nanopores can detect post-translational modifications in proteins.

Somatic cells in the mouse can be converted to a pluripotent state merely through exposure to a physical stimulus.

Capturing the interaction of promoters with their regulatory elements allows a high-resolution view into the regulatory landscape of chromatin.

Cryo-electron tomography, single-particle analysis and cross-linking mass spectroscopy join forces to solve the nuclear pore scaffold puzzle.

Cre-recombinase mouse driver lines provide tools for the functional dissection of neuronal circuits.

A set of 16 TetR proteins specific for their synthetic promoters will allow the construction of complex genetic circuits.

Chromatin immunoprecipitation of transcription factors tagged for degradation reveals how protein turnover regulates transcription.

Two groups demonstrate the use of the CRISPR-Cas9 system for genetic screens in human cells.