News & Comment

A FRET sensor enables quantitative characterization of electrostatic potential of membranes in living cells.

Proteome thermal stability is probed using limited proteolysis and mass spectrometry.

An iterative clustering approach finds the few genes that mark discrete cell states and their transitions during early mouse development.

In vitro culture of mouse embryonic and extra-embryonic stem cells recapitulates embryogenesis.

Thin slices through nuclei provide an unbiased view of the complex 3D organization of mammalian genomes.

Cryptic, widespread DNA damage is commonly interpreted as sequence variation.

A new approach measures nanoscale distances based on magnetic resonance tuning.

Bessel focus scanning and stereoscopy speed up volumetric brain imaging.

Trans-synaptic tracing that starts from a single neuron provides a detailed view of that neuron's inputs.

Cas13b relies on activator and repressor proteins to regulate RNA cleavage.

Low-energy holography enables imaging single proteins and protein complexes.

Two groups use cerebral organoids to model brain development and disease.

Light- or drug-dependent switches enable precise control over signaling pathways in living cells.

MINFLUX nanoscopy can obtain 1-nm localization precision with orders of magnitude fewer emitted photons.

Researchers have engineered a protease specific for a post-translational modification.

Researchers identify biological inhibitors of Cas9 nuclease activity and block genome editing in cultured human cells.

Donor age impacts the epigenetic state and mutational burden of induced pluripotent stem cells.

Genetically encoded reporters can be used for noninvasive cell tracking or molecular imaging with magnetic resonance imaging technologies.

Isolation of nuclei in an isotonic buffer retains chromosome loops and allows the probing of intrinsic loop conformation.