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This analysis leverages experimentally sequenced data and in silico mixtures to simulate transcript expression differences, which enables a performance assessment of long-read tools developed for isoform detection, differential transcript expression analysis and differential transcript usage analysis.
This study describes benchmarking and validation of computational tools for detecting circRNAs, finding most to be highly precise with variations in sensitivity and total detection. The study also finds over 315,000 putative human circRNAs.
This updated analysis of the Cell Tracking Challenge explores how algorithms for cell segmentation and tracking in both 2D and 3D have advanced in recent years, pointing users to high-performing tools and developers to open challenges.
This paper compares different transformation approaches for analysis of single-cell RNA-sequencing data and provides recommendations for method selection.
An international blind study confirms that smFRET measurements on dynamic proteins are highly reproducible across instruments, analysis procedures and timescales, further highlighting the promise of smFRET for dynamic structural biology.