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PRICE uses Ribo-seq data to predict ORFs and start codons with high accuracy by computationally eliminating experimental noise and dissecting overlapping translation events.
cellAlign enables quantitative comparisons of expression dynamics within and between single-cell trajectories based on single-cell RNA-seq or mass cytometry data.
CRISPR-based single-cell pooled screens that use linked barcodes suffer from lost sensitivity due to lentiviral template switching. The barcode-free CROP-seq design circumvents this problem.
A twist on a common method used for enriching phosphorylated peptides for mass spectrometry-based proteomics analysis now reveals previously undetected and widespread histidine phosphorylation in Escherichia coli.
An iterative structure factor retrieval algorithm allows electron densities to be directly calculated from solution scattering data, avoiding assumptions that limit modeling algorithms.
Chimeric receptors expressed on the surface of antigen-presenting cells enable the uptake of cancer-cell-derived extracellular vesicles and the display of tumor antigens.