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Reported is the unexpected release of polymorphonuclear neutrophilic granulocytes into the blood as a side effect of diphtheria toxin receptor–mediated dendritic cell depletion in two widely used transgenic mouse lines. The authors present a bacterial artificial chromosome transgenic mouse line that circumvents this problem.
A photoisomerizable molecule, quaternary ammonium–azobenzene–quaternary ammonium (QAQ) enables reversible optical silencing of nociceptive neurons. The selective entry of QAQ into active nociceptive neurons allows spatially and temporally precise regulation of nociceptor activity in vitro and in vivo.
To examine functional correspondences between monkey and human brain areas, a method based on the temporal correlation of sensory-evoked functional magnetic resonance imaging responses is proposed. The study reveals putative homologous regions that have shifted to topologically unexpected locations during evolution.
Comprehensive mutation libraries are an invaluable resource for screens in yeast, but anecdotal cases link phenotypes to the neighbor of a mutated gene rather than the mutant itself. The authors show that the neighboring gene effect is widespread and present software that uses protein-protein interaction networks to predict it.
Sensor proteins that exploit principles of linkage-specific avidity reveal topology-related functions of polyubiquitin in diverse cell types and pathways.
Molecular processes in cells are not spatially homogenous. Reported here is an approach, implemented in the Simmune toolset, for modeling cellular processes within their dynamic spatial context.
An imaging chamber implanted over the mouse spinal cord enables long-term longitudinal two-photon microscopy of cellular dynamics in normal or pathological conditions.
A device for generating precise spatial and temporal patterns of airborne odorants is reported. In combination with machine vision tracking software, the authors use the device to monitor navigation of freely moving Drosophila melanogaster larvae.
An acousto-optic two-photon microscope with continuous three-dimensional trajectory and random-access scanning modes can scan near-cubic-millimeter volumes of tissue at sub-millisecond temporal resolution in vivo. The system can be used to image both sub-cellular as well as network-scale neuronal activity.