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iPSC-derived midbrain dopaminergic neurons from patients with young-onset Parkinson’s disease exhibit molecular abnormalities, including elevated α-synuclein and lysosomal dysfunction, which can be normalized with phorbol ester treatment.
In a first-in-human, phase I trial in patients with B-cell lymphoma,
CD19 CAR T cells with fully human binding domains exhibit lower neurologic toxicity,
but similar clinical activity, to previously tested CD19 CAR T cells with murine
binding domains.
A newly developed PET tracer allows visualization of AMPA receptors in the living human brain, providing a new tool to study their potential involvement in neurological or psychiatric disorders.
Single-nucleus RNA sequencing in a mouse model of Aβ accumulation and postmortem brain tissue from people with Alzheimer’s disease reveals substantial species-specific differences in transcriptional signatures, but both point to the contribution of glia and the importance of TREM2.
Integrated use of an animal model, a biobank for common diseases and a rare Mendelian disease leads to the discovery of a new syndrome and its pathological mechanism.
Comprising data from over 18,000 people, a new atlas of drug–metabolite associations for 87 commonly prescribed drugs and 150 metabolites assessed by proton nuclear magnetic resonance provides a web-based tool to aid research on drug efficacy, safety and repurposing.
Cross-sectional analysis of data from the Adolescent Brain Cognitive Development Study shows that children from families with low income are at increased risk of cognitive impairment associated with high lead-exposure risk when compared with children from families with high income.