News & Comment

In people with cardiovascular disease (without diabetes) and overweight or obesity, the GLP-1 receptor agonist semaglutide significantly reduced the risk of major cardiovascular events.

The adoption of medical AI devices in clinical practice is still in its infancy, with uneven usage across procedures and locations in the USA, which underscores the inequities in its real-world implementation.

The report — the first of its kind from the WHO — is intended as a roadmap for building responsive and inclusive health systems for displaced people.

A citizen science approach has helped craft a resource-rich vaginal microbiome map with associations to lifestyle and events across a woman’s life course.

A quadrivalent vaccine against human papillomavirus produced by the Serum Institute of India was shown to be noninferior to the established quadrivalent vaccine — boosting global efforts to eliminate cervical cancer.

A machine-learning diagnosis tool, based on low-cost sequencing, can assist decision-making during brain surgeries.

A study has found that people with intermediate levels of scientific knowledge have the highest levels of overconfidence — and the most negative attitudes toward science.

Using an array of multi-omic and other technologies, scientists have comprehensively mapped the types and specialties of brain cells — revealing insights into human evolution, development and disease.

Brain insulin action, previously well studied in men, is now shown to improve peripheral insulin sensitivity during the follicular phase but not the luteal phase of the menstrual cycle.

First-line treatment with dabrafenib plus trametinib resulted in better clinical responses and lower toxicity than chemotherapy in children with BRAF V600E mutation and low-grade glioma.

As healthcare systems perform better, their resource footprints have an increasingly negative impact on the environment and health — requiring innovative strategies to break this vicious cycle.

Grown from stem cells, the models recapitulate the hallmarks of post-implantation human embryos up to day 14, opening new avenues of research into early human development.

Produce prescriptions improved fruit and vegetable intake, reduced food insecurity and improved biomarkers of cardiometabolic health, according to a large, retrospective, US-based study.

A monumental challenge to scientists due to its repetitive sequences, the human Y chromosome has now been fully sequenced — revealing new structures in regions critical for fertility.

A trial comparing long-term versus short-term antidepressant maintenance therapy fails to show a significant benefit of continued treatment.

Addition of the COX inhibitor piroxicam to levonorgestrel, a standard emergency contraceptive, increased its efficacy without increasing adverse events.

VX-548 selectively inhibits peripheral sodium channels to reduce acute pain, with potentially fewer safety concerns than for existing, nonselective blockers.

A first-in-human investigation of recombinant human antibody to ATTR shows its promise for the treatment of a rare cardiomyopathy.

Researchers have identified a naturally occurring, non–genetically modified symbiotic bacterium that inhabits the gut of mosquitoes and prevents Plasmodium transmission.

In a prospective study, artificial intelligence–assisted mammography screening had accuracy comparable to that of standard double reading — and substantially reduced radiologists’ workloads.