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The PHYSIC trial reveals substantial variability in how people respond to four different classes of blood-pressure-lowering drugs — highlighting the need to personalize treatments.
A new study provides the strongest support yet for abnormal α-synuclein as a diagnostic biomarker that shows up even in the prodromal phase — with immediate implications for trial design and therapeutic development.
A one-time gene-editing therapy restored motor function and prolonged lifespan in mice, spurring further research to refine and optimize the approach for future clinical use.
Using CAR T cells to treat solid tumors is notoriously challenging, but a new study shows impressive responses rates in children with high-risk neuroblastoma.
Decades ago, city living was associated with a height advantage in children and adolescents — but this developmental advantage has now diminished in much of the world.
An in vitro technique to drop a Y chromosome and duplicate an X chromosome could expand the reach of fertility treatments in the future, although translation to humans remains an open question.
For patients with advanced, resectable melanoma, treatment with pembrolizumab before as well as after surgery led to improved outcomes — without additional toxicity.
For people taking statins, inflammation contributes more to cardiovascular disease risk than residual cholesterol does — and could be targeted with adjunct therapy.
Existing models for predicting the 10-year risk of stroke are less accurate for Black adults than for white adults, even with the addition of novel machine-learning algorithms.
In patients with advanced melanoma, adherence to a habitual Mediterranean diet was associated with a higher probability of responding to immunotherapy.
An antibody–drug conjugate showed impressive anti-cancer activity in selected patients with platinum-resistant ovarian cancer, and could become a new standard of care.
Certain viruses — many of which have vaccines available — are linked to a significantly increased risk of neurodegenerative disease in the years following infection.
Despite concerns that bariatric surgery may increase patients’ risk of esophageal or gastric cancers, a large retrospective study offers reassurance that this is not the case.