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In a multicenter, open-label, randomized controlled trial, digital consults including digital data sharing, patient e-learning and guideline recommendations to clinicians improved guideline-directed medical therapy over the course of 12 weeks.
Infections account for the highest number of non-relapse-related deaths after CAR T cell therapy, underscoring the necessity for clinical risk-mitigating strategies and a deeper understanding of CAR T cell-related cytopenia.
Dietary guidelines advise substituting saturated fats with unsaturated fats. We used detailed blood fat composition profiling in diet trials and population studies to confirm that a moderate high-fat diet from plant oils is better for metabolism and heart health than a diet with similar fat levels from animal sources.
A large causal analysis based on a natural experiment suggests that gaming improves psychological well-being, but these benefits tapered off after more than 3 hours of gaming per day.
In the second season of a series of pragmatic trials involving all Danish citizens 65 years of age or older, electronic nudges increased influenza vaccination rates significantly with respect to usual care, with higher effect in individuals not vaccinated in the previous season.
Use of a longitudinal study design allows for more precise analysis of the interplay between clonal hematopoiesis and atherosclerotic disease, finding that whereas clonal hematopoiesis confers an increased risk of atherosclerosis, the reverse is not the case, arguing for a unidirectional effect of clonal hematopoiesis on atherosclerosis.
Researchers developed an AI-enabled, battery-operated tool that can be operated by clinicians with no sonography experience — and that measures gestational age as accurately as high-specification ultrasound.
A modeling study quantifies the health-economic burden of Lassa virus infection across West Africa and projects impacts of a series of reactive and preventive vaccination campaigns against the disease, presenting substantial impacts in terms of averted disability-adjusted life years and healthcare cost reductions.
In a digital-only study, people were more likely to take a home test if prompted to do so on the basis of self-reported symptoms rather than by wearable sensor data, with implications for public health responses and pandemic planning.
Devices that lack adequate clinical validation pose risks for patient care. A new validation standard is proposed to evaluate FDA authorization as an indication of clinical effectiveness in medical AI.
Analyses of neuroimaging datasets from 5,306 participants across 15 countries found generally larger brain-age gaps in Latin American compared with non-Latin American populations, which were influenced by disparities in socioeconomic and health-related factors.
Despite standard treatment efforts, patients with glioblastoma (GBM), an aggressive form of brain cancer, inevitably succumb to recurrent disease. Integrative genomic analyses reveal that tumor cells hijack normal neurodevelopmental pathways to promote GBM growth and invasion. To target this pathway, we engineer a CAR T cell therapy that blocks the growth of GBM and other invasive brain cancers.
An implementation trial conducted across 60 schools in Rwanda found that CyberRwanda, a digital, school-based intervention, did not affect the primary outcomes of modern contraceptive use, childbearing and HIV testing among adolescents but was associated with higher contraceptive use among sexually active participants.
In a large cohort of patients who underwent non-cardiac surgery, postoperative prescription of oral anticoagulation medication decreased the risk of stroke in patients with postoperative atrial fibrillation (POAF), especially for patients deemed to be at high risk for POAF based on a newly developed risk score.