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Howard Federoff and colleagues have identified a ten-metabolite profile in the blood that can determine with 90% certainty whether a cognitively normal elderly person will go on to develop dementia symptoms in the next 2–3 years. The findings could help with patient selection for clinical trials aimed at preventing dementia.
In sepsis, systemic inflammation leads to multiple organ failure and death. Now, Luis Ulloa and colleagues show that electroacupuncture can rescue mice from sepsis by causing the adrenal medulla to produce dopamine.
Delivery of HIV-specific neutralizing antibodies by adeno-associated virus vectors—termed vectored immunoprophylaxis (VIP)—has been shown to protect mice or macaques from intravenous infection by HIV or SIV, respectively. David Baltimore and colleagues now report that VIP is also effective at preventing HIV infection after vaginal challenge in humanized mice, suggesting that the approach might limit mucosal transmission between humans.
Gaucher's disease is a lysosomal storage disease caused by mutations in the glucocerebrosidase gene. Now, Anthony Futerman and his colleagues report that the expression of proteins linked to a form of cell death called necroptosis is increased in Gaucher's disease and that blocking these proteins can improve disease in a mouse model.
