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Volume 8 Issue 11, November 2007

Many initial encounters between host and pathogenfor example, the stinging bite of a malaria-infected mosquito (shown here)cause no disease, but when infection does take hold, a complex chain of interactions between host and pathogen occurs that defines the outcome. In a series of specially commissioned articles and additional online material, host-pathogen interactions are explored (http://www.nature.com/ni/focus/pathogenesis/). Artwork by Lewis Long.

Volume 8 Issue 11

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Editorial

  • Tremendous effort to understand how microbes influence health has brought fewer advances in treating and preventing disease than one might have expected.

    Editorial

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Overview

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Essay

  • Andrew McMichael recounts the seminal data he and colleagues produced demonstrating that cytotoxic T lymphocytes kill cells expressing antigenic peptides presented on major histocompatibility complex class I molecules.

    • Andrew J McMichael
    Essay
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Commentary

  • Relatively few studies have used live tissue microscopy to evaluate how the immune system responds to pathogens. In this commentary we discuss the challenges of imaging infectious processes and the questions that can be addressed with these dynamic approaches.

    • Peter Velázquez
    • Janelle C Waite
    • Michael L Dustin
    Commentary
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Perspective

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Review Article

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Research Highlights

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News & Views

  • The mitogen-activated protein kinases Erk and p38 transduce Toll-like receptor signals that lead to antigen capture by dendritic cells. New work identifies 'downstream' effector kinases essential for these responses and traces a pathway of mitogen-activated protein kinase signaling apparently unique to dendritic cells.

    • Michael Karin
    News & Views

  • A new study demonstrates involvement of the inhibitory receptor CTLA-4 in T cell exhaustion during infection with human immunodeficiency virus, adding complexity and diversity to the inhibitory pathways regulating T cell responses during chronic viral infections in humans.

    • Alison Crawford
    • E John Wherry
    News & Views
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Research Highlights

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Article

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Corrigendum

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Focus

  • A comprehensive overview of pathogenesis: seven specially commissioned articles discuss host-pathogen encounters from several angles, with special emphasis on immune outcomes.

    Focus
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