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Volume 3 Issue 7, July 2002

The thymus (shown here in a many-colored fluorescent technicoat) is a major center of the immune system's adaptive arm because lymphocyte precursors need its nurturing environment to commit to the T lineage. Boyd and colleagues (page 635) now report a marker, MTS24, that identifies a population of cells from which a functional thymus can be generated. See also the News & Views by Petrie on page 604.

Volume 3 Issue 7

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Editorial

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Correspondence

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Commentary

  • Higher eukaryotes can mount antiviral immune responses induced by dsRNA. This process, called RNA interference, is sequence specific and can therefore be used to target gene expression.

    • Bryan R. Cullen
    Commentary
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News & Views

  • The resolution of an immune response was thought to coincide with the clearance of infection. However, the kinetics of CD8+ T cell decline may be programmed far before the antigen load lightens.

    • Joseph N. Blattman
    • Laurence E. Cheng
    • Philip D. Greenberg
    News & Views

  • Biofilms offer cover for many pathogenic bacteria. A recent paper in Nature reveals that lactoferrin is an innate tool that inhibits biofilm formation.

    • Creg Darby
    • Scott J. Hultgren
    News & Views

  • The identity of the thymic epithelium precursor has been elusive.A marker is now shown to identify a population of cells that can give rise to a functional thymus.

    • Howard T. Petrie
    • Willem van Ewijk
    News & Views

  • TSLP is now revealed to be an important regulator of DC-mediated control of TH2-based human allergic responses, identifying a potentially new species-specific function for this cytokine.

    • Warren J. Leonard
    News & Views

  • IgE-FcεRI complex formation represents a critical step in the initiation of allergic responses. Conformational changes involving the Cε2 domain may underlie the persistent activation of FcεRI-bearing cells.

    • Natalija Novak
    • Thomas Bieber
    News & Views
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Round-up

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Review Article

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