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  • Despite considerable advances in identifying the environmental agents that trigger allergy and the immunological mechanisms involved, progress in developing effective treatments remains frustratingly slow. Is it time to rethink some of the paradigms guiding this research?

    • P G Holt
    • W R Thomas
    Commentary
  • Among the concerns surrounding genetically modified crops has been the possibility of expressing within a plant new proteins that may be allergenic. Using available technology, practical approaches have been adopted to help prevent the creation of foods that are allergenic.

    • Dean D Metcalfe
    Commentary
  • Lung mechanics, immunology, genetics, diet and endocrinology may act in a developmental context to link two complex traits: obesity and asthma.

    • Scott T Weiss
    Commentary
  • How does air pollution affect asthma and allergic rhinitis? Particulate and gaseous pollution drive proallergic inflammation through the generation of oxidative stress, which is regulated by individual genetic susceptibility.

    • Andrew Saxon
    • David Diaz-Sanchez
    Commentary