Compared with that of naive CD8+ T cells, the homeostatic population expansion of naive CD4+ T cells in a lymphopenic environment is limited. New data indicate that this difference is caused by high systemic concentrations of IL-7, which inhibit the function of dendritic cells.
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References
Grinnell, J. Auk 34, 427–433 (1917).
Guimond, M. et al. Nat. Immunol. 10, 149–157 (2009).
Polic, B., Kunkel, D., Scheffold, A. & Rajewsky, K. Proc. Natl. Acad. Sci. USA 98, 8744–8749 (2001).
Schluns, K.S., Kieper, W.C., Jameson, S.C. & Lefrancois, L. Nat. Immunol. 1, 426–432 (2000).
Tan, J.T. et al. Proc. Natl. Acad. Sci. USA 98, 8732–8737 (2001).
Kassiotis, G., Zamoyska, R. & Stockinger, B. J. Exp. Med. 197, 1007–1016 (2003).
Hakim, F.T. et al. J. Clin. Invest. 115, 930–939 (2005).
Mackall, C.L. et al. Blood 89, 3700–3707 (1997).
Bolotin, E., Annett, G., Parkman, R. & Weinberg, K. Bone Marrow Transplant. 23, 783–788 (1999).
Fry, T.J. et al. Blood 104, 2794–2800 (2004).
Kieper, W.C. et al. J. Immunol. 174, 3158–3163 (2005).
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Kaye, J. Niche marketing: regulation of the homeostasis of naive CD4+ T cells. Nat Immunol 10, 136–138 (2009). https://doi.org/10.1038/ni0209-136
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DOI: https://doi.org/10.1038/ni0209-136
