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Colorectal cancer clocks in on TIME
Immune responses are subject to circadian regulation, but circadian effects on antitumor immune response are unknown. Disruption of intestinal circadian rhythms is now shown to promote immunosuppression by altering the tumor immune microenvironment (TIME) in colorectal cancer.
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Fungal microbiota sustains lasting immune activation of neutrophils and their progenitors in severe COVID-19
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A single infusion of engineered long-lived and multifunctional T cells confers durable remission of asthma in mice
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Genetic variants in UNC93B1 predispose to childhood-onset systemic lupus erythematosus
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Cell shape sensing licenses dendritic cells for homeostatic migration to lymph nodes