Three papers characterizing human germline mutation rates bolster evidence for a relatively low rate of base substitution in modern humans and highlight a central role for paternal age in determining rates of mutation. These studies represent the advent of a transformation in our understanding of mutation rates and processes, which may ultimately have public health implications.
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Hurles, M. Older males beget more mutations. Nat Genet 44, 1174–1176 (2012). https://doi.org/10.1038/ng.2448
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DOI: https://doi.org/10.1038/ng.2448
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