Four-legged creatures may have gained a foothold by ditching genes guiding fin development.
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References
Zhang, J. et al. Nature 2010 doi:10.1038/nature09137
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Weaver, J. How fins became limbs. Nature (2010). https://doi.org/10.1038/news.2010.315
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DOI: https://doi.org/10.1038/news.2010.315