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Nusinersen (Spinraza) is a recently approved drug for treating spinal muscular atrophy. Approval of nusinersen may signal new opportunities for using antisense oligonucleotides as treatments for devastating neurological diseases.
Pregnancy results in changes to maternal physiology and brain that may extend into older age. New results show that pregnancy-induced reductions in gray matter volume remain 2 years after childbirth in humans.
The biological drive to consume salt ensures that we consume adequate sodium for survival. In this issue of Nature Neuroscience, two articles provide insight into the neurons and circuits that regulate sodium appetite.
Many spatial correlates have been identified that form the neural basis for navigation. Two studies have now uncovered a new cell type: bidirectional cells, which fire when the head is pointing in one of two opposing directions.
Representations in excitatory neurons generally narrow as they are refined. Odor representations in interneurons, however, broaden with maturation and learning, as connections between interneurons and projection neurons expand.
