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  • A large proportion of recent Brazilian Amazon deforestation is occurring on untitled public forestlands through land grabbing. This emerging risk demands long-term conservation strategies. Here we propose prioritizing land tenure security, technological improvement, and law enforcement.

    • Paulo Moutinho
    • Claudia Azevedo-Ramos
    CommentOpen Access
  • More than a decade after the first demonstration of large-scale graphene synthesis by chemical vapor deposition, the commercialization of graphene products is limited not only by price, but also by consistency, reproducibility, and predictability. Here, the author discusses the reproducibility issues in the field and proposes possible solutions to improve the reliability of published results.

    • Peter Bøggild
    CommentOpen Access
  • Searching for evidence of life on Mars is a major impetus for exploration. A new study published in Nature Communications finds that current Mars mission instruments lack the essential sensitivity to identify life traces in Chilean desert samples that strongly resemble the martian area currently under study by NASA’s Perseverance rover.

    • Carol R. Stoker
    CommentOpen Access
  • Esophageal cancers feature distinct manifestations between and within patients which complicate precision diagnosis, prognosis, and patient care. New genomic and epigenomic research uncovers novel mechanisms underlying both inter- and intra-tumoral heterogeneity in esophageal cancer, with significant biological and translational implications.

    • De-Chen Lin
    CommentOpen Access
  • Carbon dioxide removal technologies are gaining prominence in academia, industry and policy, yet the need for substantial funding raises serious challenges. This comment discusses these issues and offers suggestions for future funding efforts in this area.

    • Matthias Honegger
    CommentOpen Access
  • Prostate cancer is a highly heterogeneous disease. Progression on androgen deprivation therapy (ADT) to castration-resistant (CRPC), or neuroendocrine prostate cancer (NEPC), is associated with poor patient survival. This comment highlights recent evidence on the epigenetic mechanisms underlying the emergence of lineage plasticity and neuroendocrine differentiation in treatment-resistant prostate tumors.

    • Goutam Chakraborty
    • Kasmira Gupta
    • Natasha Kyprianou
    CommentOpen Access
  • Two new studies exploring PROTAC-mediated degradation of SMARCA2 for cancer therapy solve an apparently intractable selectivity challenge with SMARCA4 by utilising the requirement for a productive ternary complex between the protein, PROTAC and ligase complex.

    • John D. Harling
    • Christopher P. Tinworth
    CommentOpen Access