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RNF214 ubiquitin ligase is understudied. Here the authors show RNF214 promotes hepatocellular carcinoma progression by inducing non-proteolytic ubiquitylation of TEADs and activating YAP signaling pathway.
Here the authors find that mutations detected in iPSCs are de novo by analyzing 135 lines. More than 10,000 point mutations were observed in some lines and, intriguingly, CpG site-specific C>Ts were frequently identified, implying a relationship between DNA demethylation and mutagenesis.
Single-cell and spatial omics come with a trade-off between resolution and gene coverage. Here, authors bridge this gap via DOT, a multi-objective optimisation model for localising cell features in high/low-resolution spatial data considering cell composition, heterogeneity, and technical effects.
Inducible genetic mosaics can provide information about cellular lineages that are otherwise difficult to obtain. Here the authors report a mosaic knockout system called Red2Flpe-SCON, which allows lineage tracing of wild-type and mutant cells using a multicolour fluorescent reporter in mice.
Xiong et al. demonstrate the effects of non-covalent interactions between counterions and n-doped polymers on charge transport properties. They propose an approach, namely “counterion docking”, for selecting optimal counterions in doping of organic semiconductors.
Engineered sex ratio distorters have been proposed as a powerful component of genetic control strategies designed to suppress harmful insect pests. Here the authors show that sex ratio distorters behave in unexpected ways in malaria mosquitoes, offering new paths for genetic pest control by targeting sex ratios.
The b-value in earthquake size distribution shows spatiotemporal variations, being key to consider large-earthquake genesis. By high-precision focal mechanism data, we show a physical reason for the reduction in b-value before a major earthquake.
Azole antifungals are used to treat lung diseases caused by the pathogenic fungus Aspergillus fumigatus, but resistance is rising. Here, the authors generate a library of >100 protein kinase mutants of A. fumigatus, and show that loss of function or pharmacological inhibition of kinase YakA results in hypersensitivity to azoles and reduced pathogenicity.
The authors measure picosecond spin pumping in FeRh as a function of temperature by optical pump-THz emission spectroscopy. In the antiferromagnetic phase of FeRh enhanced spin pumping above the value measured in the ferromagnetic phase is observed.
Lack of stability in RuO2-based catalysts at industrial currents impedes their use in green hydrogen production. Here, the authors show that incorporating lanthanide elements into RuOx shields against external factors, enabling fine-tuned Ru-O covalency for durable oxygen evolution reaction electrocatalysis.
Semiconductor qubit architectures based on direct qubit coupling suffer from wiring fan-out and crosstalk as they scale up. Here the authors propose an architecture based on conveyor-mode shuttling of electron spins that tackles these issues and validate it numerically on quantum dot spin qubits in Si/SiGe.
This study demonstrates the opacity resolution and visual function improvement following intrastromal injection of quiescent corneal stromal keratocytes but not stromal fibroblasts. The keratocyte therapy recapitulates native cornea’s collagen fibril organization and proteoglycans.
The complexity of spatial omics data presents analytical challenges and demands substantial computing resources. Here, the authors introduce Sopa, a technology-invariant, memory-efficient pipeline with a unified visualizer for all image-based spatial omics.
Findings of sulfide-volatile compound drops preserved in the Christiana-Santorini-Kolumbo volcanic field improve understanding of the fluxes of sulfur and metals during arc magmatism and associated ore deposit formation.
Transcranial focused ultrasound (tFUS) is a non-invasive brain modulation technology with high spatiotemporal specificity. Here, authors found tFUS can significantly enhance a brain-computer interface speller by delivering low-intensity tFUS to visual cortex during the task in naïve human subjects.
Focal adhesions are force resisting, highly dynamic protein clusters. Here, the authors show that focal adhesion proteins undergo liquid-liquid phase separation on lipid membranes, shedding light on their unique properties.
The knowledge of semiconductor photocatalysis in C − H bond activation remains limited. Here, the authors report comprehensive mechanistic studies to unveil the semiconductor-rare concerted proton-coupled electron transfer mechanism for C − H bond activation over Zn-In-S.
At elevated temperatures, water microdroplets emerge near oil-water interfaces, functioning as tiny geochemical reactors that initiate interactions and mass transfer among organic and inorganic components in thermal geosystems.
To enable high-performance seasonal thermal energy storage for decarbonized solar heating, the authors propose an effective method to realize ultrastable supercooled erythritol, with an ultrahigh supercooling >150 ˚C, by making it more viscous.
It has been reported that a spaceflight causes mitochondrial stress in astronauts. Here the authors suggest that mitochondrial components are released into the plasma during spaceflight as components of CD36-marked extracellular vesicles (EVs).