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Carboxylic acids are excellent theoretical candidates for alkylation reactions given their low cost and high availability as products from traditional and also modern feedstock derivatization reactions. Here the authors use simple carboxylic acids to functionalize the C–H bonds of electron-rich arenes under electroreductive conditions with a titanium catalyst.
Activated B cells and T cells accumulate within joints of patients with rheumatoid arthritis. Here, the authors use single-cell transcriptome and repertoire profiling to identify clonally expanded synovial B cells and T cells and define their phenotypes and predicted cell-cell interactions.
The accumulation of AGEs is closely related to the atherosclerotic calcification in diabetic patients. Here, the authors find that VSMC NF90 knockout attenuates diabetic atherosclerotic calcification by mediating the metabolic imbalance of AGEs.
The molecular mechanisms underlying metabolic remodelling in colorectal cancer (CRC) are not completely elucidated. Here, they authors show that the oncogenic protein MYG1 promotes CRC progression not only through regulating mitochondrial activity, but also through activating a nuclear-associated pathway for glycolysis increase.
Sickle cell disease is a blood disorder that originates from a single point mutation in the HBB gene that codes for hemoglobin. Here, Moiani et al. developed an efficient TALEN-mediated HBB correction process that is compatible with gene therapy applications.
A major advantage of antiferromagnets for applications is the lack of stray fields and insensitivity to magneto-electric perturbations, however, this also makes electric control of AFMs challenging. Here, focusing on a non-collinear AFM, Mn3Ge/Sn, Wu et al demonstrate fast domain wall motion, with remarkably low current density, and extend our understanding of spin-transfer torques that drive this to noncollinear antiferromagnetic systems.
New technologies assay tissue slices for cell locations and molecular markers, aiding in the study of tissue cellular organisation. Here, authors develop an experimental design method to improve the cost-efficiency of spatial genomics experiments by iteratively selecting the most informative tissue slices.
Here the authors develop a dispersive Fourier transform (DFT) based LIDAR method utilizing phase-locked Vernier dual soliton laser combs and demonstrate improved precision in the measurements.
Devices based on microbial biofilms can be used to generate hydrovoltaic energy from water evaporation. Here, Ren et al. show that, in addition, electroautotrophic bacteria can use evaporation-induced hydrovoltaic electrons for growth in biofilms.
Here the authors report spaceflight secretome profiles by integrating plasma proteome, metabolome, and extracellular vesicles/particles proteome from the SpaceX Inspiration4 crew, which showed differences in coagulation, oxidative stress, and brain-enriched proteins.
The phenotype and function of immune cells could change during spaceflight. Here the authors use simulated microgravity, coupled to validation with spaceflight data, to assess whether there are distinct gene expression changes in resting and TLR 7/8 stimulated PBMCs and found conserved changes in IFN signalling, the cytoskeleton, IL-6 and sirtuin signalling.
Twisted 2D magnets provide a rich playground for potential spintronic device architectures. Here, the authors use tunneling magnetoresistance measurements to investigate the collective spin states of twisted double bilayer CrI3 in various configurations, providing evidence of non-volatile spin textures.
Evolution of viviparity supports expansion into cold habitats. Here, the authors examine viviparity with patterns and rates of body size evolution in female Liolaemus lizards, finding that viviparous species are 20% larger with similar rates of evolution.
Here the authors provide the biospecimen collection methodology from the SpaceX Inspiration4 mission, including venous blood, capillary blood, saliva, urine, stool, skin biopsy, body swab, and environmental swab samples.
Siew et al. using multi-omic, physiological & imaging approaches have demonstrated that spaceflight causes kidney remodelling, suggesting a contribution to kidney stone formation, & that space radiation causes kidney damage & early signs of dysfunction.
Here the authors explore the role of chemical modifications within RNA molecules in spaceflight response, observing increased m6A mRNA modifications immediately post-spaceflight in gene markers associated with stress response.
Here the authors profile skin microenvironment changes in response to spaceflight by performing a multi omics analysis using skin punch biopsies from the crew members of SpaceX Inspiration4 mission comparing before, post launch and one day after return 91 of the 3-day mission.
The authors present a diffractive optical processor that approximates optical phase conjugation operation without any digital computing. This compact and all-optical wavefront processor can be used for various applications, including turbidity suppression and aberration correction.
Acetylation of histone lysine residues correlates with transcription activation, but it is currently debated whether histone acetylation is a cause or a consequence of transcription. Here, the authors show how global protein acetylation remains unaltered after acute inhibition of transcription, indicating that histone acetylation is not merely a consequence of transcription.
The classification of magnets now includes altermagnets which possess opposite-spin sublattices connected by rotation and share some features with ferro- and antiferromagnets. Here the authors report the anomalous Hall effect in Mn5Si3 and interpret the results in terms of a d-wave altermagnetic phase.