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  • The authors observe multiferroicity in a single-layer non van der Waals material, CuCrSe2. The coexistence of room-temperature ferroelectricity and ferromagnetism up to 120 K is corroborated by a set of comprehensive experimental techniques.

    • Zhenyu Sun
    • Yueqi Su
    • Baojie Feng
    ArticleOpen Access
  • The band topology of twisted 2D systems is a key factor behind their fascinating physics. Here, the authors demonstrate the role of polarization in driving the band topology evolution in twisted transition metal dichalcogenide homobilayers.

    • Xiao-Wei Zhang
    • Chong Wang
    • Di Xiao
    ArticleOpen Access
  • Methionine plays an essential role in various biological and cell regulatory processes, making its chemoproteomic profiling necessary to understand its function. Here, the authors present Copper(I)-Nitrene Platform (CuNiP) for robust and selective labelling of methionine to generate highly stable sulfonyl sulfimide conjugates under physiological conditions.

    • Samrat Sahu
    • Benjamin Emenike
    • Monika Raj
    ArticleOpen Access
  • Trade-offs play a key role in controlling bacterial growth and shaping microbial phenotypes, which further drives the emergence of ecologically relevant phenomena including co-existence, population heterogeneity and oligotrophic/copiotrophic lifestyles.

    • Manlu Zhu
    • Xiongfeng Dai
    Review ArticleOpen Access
  • Predicting the response to platinum-based chemotherapy in high-grade serous ovarian carcinoma (HGSOC) remains challenging. Here, the authors develop the histopathology image-based Pathologic Risk Classifier for HGSOC - PathoRiCH - to predict and stratify HGSOC patient response to therapy, especially when combined with molecular biomarkers.

    • Byungsoo Ahn
    • Damin Moon
    • Eunhyang Park
    ArticleOpen Access
  • Existing proposals of axion insulators are limited to spin-1/2 systems. Here the authors put forward a concept of a high spin axion insulator with several peculiar properties, such as the absence of gapless surface states and tunability of the axion field by an external magnetic field.

    • Shuai Li
    • Ming Gong
    • X. C. Xie
    ArticleOpen Access
  • At the quantum limit, vacuum fluctuations determine the precision with which a signal can be measured. In this work the authors use a technique known as squeezing to greatly reduce the vacuum fluctuation noise present at microwave frequencies.

    • Arjen Vaartjes
    • Anders Kringhøj
    • Jarryd J. Pla
    ArticleOpen Access
  • Asymmetric mechanical transducers are pivotal in various applications; however, conventional methods demand continuous energy and intricate fabrication. Here, the authors demonstrate a droplet-based mechanical transducer utilizing wettability-patterned surfaces, enabling precise control of droplet dynamics.

    • Luanluan Xue
    • An Li
    • Yanlin Song
    ArticleOpen Access
  • Despite initial treatment with surgical resection, glioblastoma multiforme (GBM) frequently recurs. Here the authors report the design of an immunostimulatory autolysing Salmonella based-nanocapsule delivery system, promoting anti-tumor immune responses and preventing postoperative relapse in preclinical GBM models.

    • Yulin Zhang
    • Kaiyan Xi
    • Shilei Ni
    ArticleOpen Access
  • Dielectric elastomer actuators require high driving electric fields to achieve high performances for soft robots due to their low dielectric constant and high stiffness. Here, the authors introduce polar fluorinated groups and nanodomains aggregated by long alkyl side chains into the dielectric elastomer design to overcome these issues and develop fast soft robots.

    • Wenwen Feng
    • Lin Sun
    • Chao Wang
    ArticleOpen Access
  • Using machine learning algorithms, this study estimates sea level rise and high tide flooding thresholds every 10 km along the United States’ coasts, complementing conventional linear-/point-based estimates and offering insights for ungauged areas.

    • Sadaf Mahmoudi
    • Hamed Moftakhari
    • Hamid Moradkhani
    ArticleOpen Access
  • Hsc70 (heat shock protein family A member 8) is a cytoplasmic chaperone protein involved in endosomal micro-autophagy and chaperone-mediated autophagy. Here the authors report that Hsc70 promotes lysosomal degradation of PD-L1 and that its overexpression promotes anti-tumor immune responses in preclinical cancer models.

    • Xiaoyan Xu
    • Tingxue Xie
    • Hongguang Xia
    ArticleOpen Access