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Photorhabdus noenieputensis (a gut microbiota symbiont of nematodes) produces a macrocyclic antibiotic, evybactin, that selectively kills Mycobacterium tuberculosis (Mtb). The Mtb membrane transporter BacA imports evybactin into the cell, where it binds to DNA gyrase and causes cell death.
The microtubule-associated protein tau is strongly linked to Alzheimer’s disease, but the physiological functions of tau on microtubules remain unclear. New experiments reveal that tau recognizes and alters the conformation of the underlying microtubule lattice by forming envelopes that surround its surface, suggestive of a novel role for tau in cell physiology.
