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X-ray crystallographic analysis of thymine DNA glycosylase (TDG) in complex with DNA containing 5-carboxylcytosine (5caC) analogs reveals that 5caC is a preferred substrate of TDG, providing support for a 5-methylcytosine demethylation pathway involving 5-methylcytosine oxidation and removal by base-excision repair glycosylases.
Untargeted metabolomics reveals a dysregulation of sphingolipid production during neuropathic pain exemplified by N,N-dimethylsphingosine, whose upregulation is involved in the generation of pain.
