Providing chemical matter to modulate newly identified biological targets—as well as pre-existing but chemically intractable ones—remains a challenge in the discovery of therapeutics. Here, we discuss opportunities for synthetic chemists to make a direct impact in addressing targets that are considered 'undruggable'.
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Kesavan, S., Marcaurelle, L. Translational synthetic chemistry. Nat Chem Biol 9, 210–213 (2013). https://doi.org/10.1038/nchembio.1207
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DOI: https://doi.org/10.1038/nchembio.1207