In response to decreasing Ca2+ levels in the endoplasmic reticulum, STIM proteins couple with Orai channels in the plasma membrane, leading to Ca2+ influx into the cell. In addition to Ca2+-related endoplasmic reticulum stress, STIM proteins are emerging as general stress sensors that react to multiple stress signals to orchestrate Ca2+ signaling and homeostasis.
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The research performed by D.L.G. for this manuscript was partly supported by Novartis Institutes for Biomedical Research.
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Soboloff, J., Madesh, M. & Gill, D. Sensing cellular stress through STIM proteins. Nat Chem Biol 7, 488–492 (2011). https://doi.org/10.1038/nchembio.619
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DOI: https://doi.org/10.1038/nchembio.619
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